Lee H - Search Results

1

Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling.

Lee H, Ren J, Pesavento RP, Ojeda I, Rice AJ, Lv H, Kwon Y, Johnson ME. Lee H, et al. Bioorg Med Chem. 2019 May 15;27(10):1981-1989. doi: 10.1016/j.bmc.2019.03.050. Epub 2019 Mar 26. Bioorg Med Chem. 2019. PMID: 30940566 Free PMC article.

2

Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: lee h. J Med Chem. 2010 Jul 8;53(13):4968-79. doi: 10.1021/jm1004489. J Med Chem. 2010. PMID: 20527968 Free PMC article.

3

Reducing agents affect inhibitory activities of compounds: results from multiple drug targets.

Lee H, Torres J, Truong L, Chaudhuri R, Mittal A, Johnson ME. Lee H, et al. Anal Biochem. 2012 Apr 1;423(1):46-53. doi: 10.1016/j.ab.2012.01.006. Epub 2012 Jan 18. Anal Biochem. 2012. PMID: 22310499 Free PMC article.

4

Identification of non-macrocyclic small molecule inhibitors against the NS3/4A serine protease of hepatitis C virus through in silico screening.

Chaudhuri R, Lee H, Truong L, Torres J, Patel K, Johnson ME. Chaudhuri R, et al. Among authors: lee h. J Chem Inf Model. 2012 Aug 27;52(8):2245-56. doi: 10.1021/ci300177p. Epub 2012 Jul 20. J Chem Inf Model. 2012. PMID: 22697413

5

High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion.

Truong L, Hevener KE, Rice AJ, Patel K, Johnson ME, Lee H. Truong L, et al. Among authors: lee h. Protein Expr Purif. 2013 Mar;88(1):98-106. doi: 10.1016/j.pep.2012.11.018. Epub 2012 Dec 13. Protein Expr Purif. 2013. PMID: 23246866 Free PMC article.

6

Fragment-based drug discovery using a multidomain, parallel MD-MM/PBSA screening protocol.

Zhu T, Lee H, Lei H, Jones C, Patel K, Johnson ME, Hevener KE. Zhu T, et al. Among authors: lee h. J Chem Inf Model. 2013 Mar 25;53(3):560-72. doi: 10.1021/ci300502h. Epub 2013 Mar 14. J Chem Inf Model. 2013. PMID: 23432621 Free PMC article.

7

A colorimetric assay optimization for high-throughput screening of dihydroorotase by detecting ureido groups.

Rice AJ, Truong L, Johnson ME, Lee H. Rice AJ, et al. Among authors: lee h. Anal Biochem. 2013 Oct 1;441(1):87-94. doi: 10.1016/j.ab.2013.05.035. Epub 2013 Jun 13. Anal Biochem. 2013. PMID: 23769705

8

Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.

Lee H, Cao S, Hevener KE, Truong L, Gatuz JL, Patel K, Ghosh AK, Johnson ME. Lee H, et al. ChemMedChem. 2013 Aug;8(8):1361-72. doi: 10.1002/cmdc.201300134. Epub 2013 Jun 20. ChemMedChem. 2013. PMID: 23788528 Free PMC article.

9

High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes.

Lee H, Zhu T, Patel K, Zhang YY, Truong L, Hevener KE, Gatuz JL, Subramanya G, Jeong HY, Uprichard SL, Johnson ME. Lee H, et al. PLoS One. 2013 Oct 9;8(10):e75144. doi: 10.1371/journal.pone.0075144. eCollection 2013. PLoS One. 2013. PMID: 24130685 Free PMC article.

10

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.

Lee H, Mittal A, Patel K, Gatuz JL, Truong L, Torres J, Mulhearn DC, Johnson ME. Lee H, et al. Bioorg Med Chem. 2014 Jan 1;22(1):167-77. doi: 10.1016/j.bmc.2013.11.041. Epub 2013 Dec 1. Bioorg Med Chem. 2014. PMID: 24332657 Free PMC article.

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