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Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas.
Kukita A, Sone K, Oda K, Hamamoto R, Kaneko S, Komatsu M, Wada M, Honjoh H, Kawata Y, Kojima M, Oki S, Sato M, Asada K, Taguchi A, Miyasaka A, Tanikawa M, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Osuga Y, Fujii T. Kukita A, et al. Among authors: honjoh h. Biochem Biophys Res Commun. 2019 May 28;513(2):340-346. doi: 10.1016/j.bbrc.2019.03.155. Epub 2019 Apr 4. Biochem Biophys Res Commun. 2019. PMID: 30955858
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Akino N, Wada-Hiraike O, Terao H, Honjoh H, Isono W, Fu H, Hirano M, Miyamoto Y, Tanikawa M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Kawana K, Fujii T, Osuga Y. Akino N, et al. Among authors: honjoh h. Mol Cell Endocrinol. 2018 Jul 15;470:96-104. doi: 10.1016/j.mce.2017.10.002. Epub 2017 Oct 4. Mol Cell Endocrinol. 2018. PMID: 28986302
The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation.
Kojima M, Sone K, Oda K, Hamamoto R, Kaneko S, Oki S, Kukita A, Machino H, Honjoh H, Kawata Y, Kashiyama T, Asada K, Tanikawa M, Mori-Uchino M, Tsuruga T, Nagasaka K, Matsumoto Y, Wada-Hiraike O, Osuga Y, Fujii T. Kojima M, et al. Among authors: honjoh h. BMC Cancer. 2019 May 15;19(1):455. doi: 10.1186/s12885-019-5638-9. BMC Cancer. 2019. PMID: 31092221 Free PMC article.
The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells.
Kojima M, Sone K, Oda K, Hamamoto R, Kaneko S, Oki S, Kukita A, Kawata A, Honjoh H, Kawata Y, Kashiyama T, Sato M, Taguchi A, Miyamoto Y, Tanikawa M, Tsuruga T, Nagasaka K, Wada-Hiraike O, Osuga Y, Fujii T. Kojima M, et al. Among authors: honjoh h. Oncol Lett. 2020 Nov;20(5):153. doi: 10.3892/ol.2020.12014. Epub 2020 Aug 24. Oncol Lett. 2020. PMID: 32934721 Free PMC article.
Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer.
Wada M, Kukita A, Sone K, Hamamoto R, Kaneko S, Komatsu M, Takahashi Y, Inoue F, Kojima M, Honjoh H, Taguchi A, Kashiyama T, Miyamoto Y, Tanikawa M, Tsuruga T, Mori-Uchino M, Wada-Hiraike O, Osuga Y, Fujii T. Wada M, et al. Among authors: honjoh h. Biomolecules. 2020 Dec 16;10(12):1686. doi: 10.3390/biom10121686. Biomolecules. 2020. PMID: 33339442 Free PMC article.
Histone arginine methyltransferase CARM1 selective inhibitor TP-064 induces apoptosis in endometrial cancer.
Inoue F, Sone K, Toyohara Y, Tanimoto S, Takahashi Y, Kusakabe M, Kukita A, Honjoh H, Nishijima A, Taguchi A, Miyamoto Y, Tanikawa M, Iriyama T, Uchino MM, Tsuruga T, Wada-Hiraike O, Oda K, Osuga Y. Inoue F, et al. Among authors: honjoh h. Biochem Biophys Res Commun. 2022 Apr 23;601:123-128. doi: 10.1016/j.bbrc.2022.02.086. Epub 2022 Feb 23. Biochem Biophys Res Commun. 2022. PMID: 35245741
Heterogeneous effects of cytotoxic chemotherapies for platinum-resistant ovarian cancer.
Nara K, Taguchi A, Yamamoto T, Hara K, Tojima Y, Honjoh H, Nishijima A, Eguchi S, Miyamoto Y, Sone K, Mori M, Takada T, Osuga Y. Nara K, et al. Among authors: honjoh h. Int J Clin Oncol. 2023 Sep;28(9):1207-1217. doi: 10.1007/s10147-023-02367-1. Epub 2023 Jun 22. Int J Clin Oncol. 2023. PMID: 37347381 Free PMC article.
17 results