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Page 1
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, Bassett A, Karran E, Miller BL, Fleming A, Rubinsztein DC. Siddiqi FH, et al. Among authors: rubinsztein dc. Nat Commun. 2019 Apr 18;10(1):1817. doi: 10.1038/s41467-019-09494-2. Nat Commun. 2019. PMID: 31000720 Free PMC article.
Rapamycin alleviates toxicity of different aggregate-prone proteins.
Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC. Berger Z, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2006 Feb 1;15(3):433-42. doi: 10.1093/hmg/ddi458. Epub 2005 Dec 20. Hum Mol Genet. 2006. PMID: 16368705
Potential therapeutic applications of autophagy.
Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Rubinsztein DC, et al. Nat Rev Drug Discov. 2007 Apr;6(4):304-12. doi: 10.1038/nrd2272. Nat Rev Drug Discov. 2007. PMID: 17396135 Review.
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.
Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Among authors: rubinsztein dc. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.
450 results