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A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Karnell JL, Albulescu M, Drabic S, Wang L, Moate R, Baca M, Oganesyan V, Gunsior M, Thisted T, Yan L, Li J, Xiong X, Eck SC, de Los Reyes M, Yusuf I, Streicher K, Müller-Ladner U, Howe D, Ettinger R, Herbst R, Drappa J. Karnell JL, et al. Among authors: eck sc. Sci Transl Med. 2019 Apr 24;11(489):eaar6584. doi: 10.1126/scitranslmed.aar6584. Sci Transl Med. 2019. PMID: 31019027
Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses.
Chen B, Vousden KA, Naiman B, Turman S, Sun H, Wang S, Vinall LMK, Kemp BP, Kasturiangan S, Rees DG, Grant E, Hinrichs MJ, Eck S, DiGiandomenico A, Jack Borrok M, Ly N, Xiong X, Gonzalez C, Morehouse C, Wang Y, Zhou Y, Cann J, Zhao W, Koelkebeck H, Okubo K, Mayadas TN, Howe D, Griffiths J, Kolbeck R, Herbst R, Sims GP. Chen B, et al. Ann Rheum Dis. 2019 Feb;78(2):228-237. doi: 10.1136/annrheumdis-2018-213523. Epub 2018 Nov 20. Ann Rheum Dis. 2019. PMID: 30459279 Free PMC article.
Effects of ICOS+ T cell depletion via afucosylated monoclonal antibody MEDI-570 on pregnant cynomolgus monkeys and the developing offspring.
Nicholson SM, Carlesso G, Cheng LI, Cook H, DaCosta K, Leininger J, McKeever K, Scott SW, Taylor D, Streicher K, Eck S, Reed M, Faggioni R, Herbst R, Dixit R, Ryan PC. Nicholson SM, et al. Reprod Toxicol. 2017 Dec;74:116-133. doi: 10.1016/j.reprotox.2017.08.018. Epub 2017 Sep 13. Reprod Toxicol. 2017. PMID: 28916434
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
Zhang Q, Lee B, Korecka M, Li G, Weyland C, Eck S, Gessain A, Arima N, Lessin SR, Shaw LM, Luger S, Kamoun M, Wasik MA. Zhang Q, et al. Leuk Res. 1999 Apr;23(4):373-84. doi: 10.1016/s0145-2126(98)00173-8. Leuk Res. 1999. PMID: 10229324 Free article.