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Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.
O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM, Waddell SJ, Ward SE, Richardson GP, Kros CJ, Derudas M. O'Reilly M, et al. Among authors: kirkwood nk. J Med Chem. 2019 Jun 13;62(11):5312-5329. doi: 10.1021/acs.jmedchem.8b01325. Epub 2019 May 24. J Med Chem. 2019. PMID: 31083995 Free article.
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.
Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN. Quick K, et al. Open Biol. 2012 May;2(5):120068. doi: 10.1098/rsob.120068. Open Biol. 2012. PMID: 22724068 Free PMC article.
ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity.
Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP, Kros CJ. Kitcher SR, et al. Among authors: kirkwood nk. JCI Insight. 2019 Aug 8;4(15):e126764. doi: 10.1172/jci.insight.126764. eCollection 2019 Aug 8. JCI Insight. 2019. PMID: 31391343 Free PMC article.
Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity.
Kenyon EJ, Kirkwood NK, Kitcher SR, Goodyear RJ, Derudas M, Cantillon DM, Baxendale S, de la Vega de León A, Mahieu VN, Osgood RT, Wilson CD, Bull JC, Waddell SJ, Whitfield TT, Ward SE, Kros CJ, Richardson GP. Kenyon EJ, et al. Among authors: kirkwood nk. JCI Insight. 2021 Apr 8;6(7):e145704. doi: 10.1172/jci.insight.145704. JCI Insight. 2021. PMID: 33735112 Free PMC article.
Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives.
Derudas M, O'Reilly M, Kirkwood NK, Kenyon EJ, Grimsey S, Kitcher SR, Workman S, Bull JC, Ward SE, Kros CJ, Richardson GP. Derudas M, et al. Among authors: kirkwood nk. Front Cell Dev Biol. 2023 Oct 10;11:1247324. doi: 10.3389/fcell.2023.1247324. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37900280 Free PMC article.
12 results