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Positron Emission Tomography Imaging of [11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A.
Billington S, Shoner S, Lee S, Clark-Snustad K, Pennington M, Lewis D, Muzi M, Rene S, Lee J, Nguyen TB, Kumar V, Ishida K, Chen L, Chu X, Lai Y, Salphati L, Hop CECA, Xiao G, Liao M, Unadkat JD. Billington S, et al. Among authors: lai y. Clin Pharmacol Ther. 2019 Nov;106(5):1056-1066. doi: 10.1002/cpt.1506. Epub 2019 Jul 22. Clin Pharmacol Ther. 2019. PMID: 31102467 Free PMC article. Clinical Trial.
Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine.
Lee EW, Lai Y, Zhang H, Unadkat JD. Lee EW, et al. Among authors: lai y. J Biol Chem. 2006 Jun 16;281(24):16700-6. doi: 10.1074/jbc.M513825200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595656 Free article.
We have previously shown that the human equilibrative nucleoside transporter 1 (hENT1) is expressed and functional in the mitochondrial membrane and that this expression enhances the mitochondrial toxicity of the nucleoside drug, fialuridine (FIAU) (Lai, Y., Tse, C. …
We have previously shown that the human equilibrative nucleoside transporter 1 (hENT1) is expressed and functional in the mitochondrial memb …
In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta.
Govindarajan R, Bakken AH, Hudkins KL, Lai Y, Casado FJ, Pastor-Anglada M, Tse CM, Hayashi J, Unadkat JD. Govindarajan R, et al. Among authors: lai y. Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1809-22. doi: 10.1152/ajpregu.00293.2007. Epub 2007 Aug 29. Am J Physiol Regul Integr Comp Physiol. 2007. PMID: 17761511 Free article.
Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).
Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC. Lai Y, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. doi: 10.1124/jpet.110.170753. Epub 2010 Jun 2. J Pharmacol Exp Ther. 2010. PMID: 20519552 Clinical Trial.
9,136 results