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Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment.
Deshmukh V, O'Green AL, Bossard C, Seo T, Lamangan L, Ibanez M, Ghias A, Lai C, Do L, Cho S, Cahiwat J, Chiu K, Pedraza M, Anderson S, Harris R, Dellamary L, Kc S, Barroga C, Melchior B, Tam B, Kennedy S, Tambiah J, Hood J, Yazici Y. Deshmukh V, et al. Osteoarthritis Cartilage. 2019 Sep;27(9):1347-1360. doi: 10.1016/j.joca.2019.05.006. Epub 2019 May 25. Osteoarthritis Cartilage. 2019. PMID: 31132406 Free article.
The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models.
Tam BY, Chiu K, Chung H, Bossard C, Nguyen JD, Creger E, Eastman BW, Mak CC, Ibanez M, Ghias A, Cahiwat J, Do L, Cho S, Nguyen J, Deshmukh V, Stewart J, Chen CW, Barroga C, Dellamary L, Kc SK, Phalen TJ, Hood J, Cha S, Yazici Y. Tam BY, et al. Among authors: deshmukh v. Cancer Lett. 2020 Mar 31;473:186-197. doi: 10.1016/j.canlet.2019.09.009. Epub 2019 Sep 24. Cancer Lett. 2020. PMID: 31560935 Free article.
A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.
Deshmukh V, Hu H, Barroga C, Bossard C, Kc S, Dellamary L, Stewart J, Chiu K, Ibanez M, Pedraza M, Seo T, Do L, Cho S, Cahiwat J, Tam B, Tambiah JRS, Hood J, Lane NE, Yazici Y. Deshmukh V, et al. Osteoarthritis Cartilage. 2018 Jan;26(1):18-27. doi: 10.1016/j.joca.2017.08.015. Epub 2017 Sep 6. Osteoarthritis Cartilage. 2018. PMID: 28888902 Free article.
Small-molecule inducer of β cell proliferation identified by high-throughput screening.
Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Shen W, et al. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. doi: 10.1021/ja309304m. Epub 2013 Jan 25. J Am Chem Soc. 2013. PMID: 23330637
Small molecule mediated proliferation of primary retinal pigment epithelial cells.
Swoboda JG, Elliott J, Deshmukh V, de Lichtervelde L, Shen W, Tremblay MS, Peters EC, Cho CY, Lu B, Girman S, Wang S, Schultz PG. Swoboda JG, et al. Among authors: deshmukh v. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. doi: 10.1021/cb4001712. Epub 2013 May 8. ACS Chem Biol. 2013. PMID: 23621521 Free PMC article.
An immunosuppressive antibody-drug conjugate.
Wang RE, Liu T, Wang Y, Cao Y, Du J, Luo X, Deshmukh V, Kim CH, Lawson BR, Tremblay MS, Young TS, Kazane SA, Wang F, Schultz PG. Wang RE, et al. Among authors: deshmukh v. J Am Chem Soc. 2015 Mar 11;137(9):3229-32. doi: 10.1021/jacs.5b00620. Epub 2015 Feb 27. J Am Chem Soc. 2015. PMID: 25699419 Free PMC article.
A regenerative approach to the treatment of multiple sclerosis.
Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. Deshmukh VA, et al. Nature. 2013 Oct 17;502(7471):327-332. doi: 10.1038/nature12647. Epub 2013 Oct 9. Nature. 2013. PMID: 24107995 Free PMC article.
334 results