Zhang R - Search Results

1

Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR^{L858R/T790M/C797S}).

Shen J, Zhang T, Zhu SJ, Sun M, Tong L, Lai M, Zhang R, Xu W, Wu R, Ding J, Yun CH, Xie H, Lu X, Ding K. Shen J, et al. Among authors: zhang r, zhang t. J Med Chem. 2019 Aug 8;62(15):7302-7308. doi: 10.1021/acs.jmedchem.9b00576. Epub 2019 Jul 23. J Med Chem. 2019. PMID: 31298540

2

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.

Pratt JK, Donner P, McDaniel KF, Maring CJ, Kati WM, Mo H, Middleton T, Liu Y, Ng T, Xie Q, Zhang R, Montgomery D, Molla A, Kempf DJ, Kohlbrenner W. Pratt JK, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1577-82. doi: 10.1016/j.bmcl.2005.01.071. Bioorg Med Chem Lett. 2005. PMID: 15745800

3

Discovery of a new class of JMJD6 inhibitors and structure-activity relationship study.

Wang T, Zhang R, Liu Y, Fang Z, Zhang H, Fan Y, Yang S, Xiang R. Wang T, et al. Among authors: zhang r, zhang h. Bioorg Med Chem Lett. 2021 Jul 15;44:128109. doi: 10.1016/j.bmcl.2021.128109. Epub 2021 May 13. Bioorg Med Chem Lett. 2021. PMID: 33991627

4

Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.

Fang Z, Liu Y, Zhang R, Chen Q, Wang T, Yang W, Fan Y, Yu C, Xiang R, Yang S. Fang Z, et al. Among authors: zhang r. Eur J Med Chem. 2021 Nov 5;223:113662. doi: 10.1016/j.ejmech.2021.113662. Epub 2021 Jun 26. Eur J Med Chem. 2021. PMID: 34237635

5

Discovery of a potent, selective and cell active inhibitor of m⁶A demethylase ALKBH5.

Fang Z, Mu B, Liu Y, Guo N, Xiong L, Guo Y, Xia A, Zhang R, Zhang H, Yao R, Fan Y, Li L, Yang S, Xiang R. Fang Z, et al. Among authors: zhang r, zhang h. Eur J Med Chem. 2022 Aug 5;238:114446. doi: 10.1016/j.ejmech.2022.114446. Epub 2022 May 11. Eur J Med Chem. 2022. PMID: 35597008

6

Synthesis and Bioevaluation of 3-(Arylmethylene)indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities.

Feng L, Chen X, Sheng G, Li Y, Li Y, Zhang Y, Yao K, Wu Z, Zhang R, Kiboku T, Kawasaki A, Horimoto K, Tang Y, Sun M, Han F, Chen D. Feng L, et al. Among authors: zhang r, zhang y. J Med Chem. 2023 Nov 9;66(21):14609-14622. doi: 10.1021/acs.jmedchem.3c01090. Epub 2023 Oct 20. J Med Chem. 2023. PMID: 37861443

7

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.

Krueger AC, Madigan DL, Jiang WW, Kati WM, Liu D, Liu Y, Maring CJ, Masse S, McDaniel KF, Middleton T, Mo H, Molla A, Montgomery D, Pratt JK, Rockway TW, Zhang R, Kempf DJ. Krueger AC, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3367-70. doi: 10.1016/j.bmcl.2006.04.015. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650764

8

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.

Rockway TW, Zhang R, Liu D, Betebenner DA, McDaniel KF, Pratt JK, Beno D, Montgomery D, Jiang WW, Masse S, Kati WM, Middleton T, Molla A, Maring CJ, Kempf DJ. Rockway TW, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3833-8. doi: 10.1016/j.bmcl.2006.04.022. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650984

9

Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy.

Liu C, Ji X, Yu Z, Zhang S, Zhang R, Zhao W, Dong X. Liu C, et al. Among authors: zhang r, zhang s. J Med Chem. 2023 Jun 8;66(11):7205-7220. doi: 10.1021/acs.jmedchem.2c01653. Epub 2023 May 19. J Med Chem. 2023. PMID: 37204432

10

Corrigendum to "Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5" [Eur. J. Med. Chem. 238 (2022) 114446].

Fang Z, Mu B, Liu Y, Guo N, Xiong L, Guo Y, Xia A, Zhang R, Zhang H, Yao R, Fan Y, Li L, Yang S, Xiang R. Fang Z, et al. Among authors: zhang r, zhang h. Eur J Med Chem. 2023 Jul 5;255:115368. doi: 10.1016/j.ejmech.2023.115368. Epub 2023 Apr 27. Eur J Med Chem. 2023. PMID: 37119665 No abstract available.

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