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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.
Nat Commun. 2019 Jul 18;10(1):3187. doi: 10.1038/s41467-019-11227-4.
Nat Commun. 2019.
PMID: 31320633
Free PMC article.
Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy.
Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M, Rüegg MA.
Castets P, et al. Among authors: rion n.
Cell Metab. 2013 May 7;17(5):731-44. doi: 10.1016/j.cmet.2013.03.015. Epub 2013 Apr 18.
Cell Metab. 2013.
PMID: 23602450
Free article.
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LncRNA-encoded peptides: More than translational noise?
Rion N, Rüegg MA.
Rion N, et al.
Cell Res. 2017 May;27(5):604-605. doi: 10.1038/cr.2017.35. Epub 2017 Mar 14.
Cell Res. 2017.
PMID: 28290465
Free PMC article.
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mTOR controls embryonic and adult myogenesis via mTORC1.
Rion N, Castets P, Lin S, Enderle L, Reinhard JR, Eickhorst C, Rüegg MA.
Rion N, et al.
Development. 2019 Apr 8;146(7):dev172460. doi: 10.1242/dev.172460.
Development. 2019.
PMID: 30872276
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mTORC2 affects the maintenance of the muscle stem cell pool.
Rion N, Castets P, Lin S, Enderle L, Reinhard JR, Rüegg MA.
Rion N, et al.
Skelet Muscle. 2019 Dec 2;9(1):30. doi: 10.1186/s13395-019-0217-y.
Skelet Muscle. 2019.
PMID: 31791403
Free PMC article.
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.
Brockhoff M, Rion N, Chojnowska K, Wiktorowicz T, Eickhorst C, Erne B, Frank S, Angelini C, Furling D, Rüegg MA, Sinnreich M, Castets P.
Brockhoff M, et al. Among authors: rion n.
J Clin Invest. 2017 Feb 1;127(2):549-563. doi: 10.1172/JCI89616. Epub 2017 Jan 9.
J Clin Invest. 2017.
PMID: 28067669
Free PMC article.
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