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An LKB1-SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation.
Murray CW, Brady JJ, Tsai MK, Li C, Winters IP, Tang R, Andrejka L, Ma RK, Kunder CA, Chu P, Winslow MM. Murray CW, et al. Among authors: tsai mk. Cancer Discov. 2019 Nov;9(11):1590-1605. doi: 10.1158/2159-8290.CD-18-1237. Epub 2019 Jul 26. Cancer Discov. 2019. PMID: 31350327 Free PMC article.
A versatile system to record cell-cell interactions.
Tang R, Murray CW, Linde IL, Kramer NJ, Lyu Z, Tsai MK, Chen LC, Cai H, Gitler AD, Engleman E, Lee W, Winslow MM. Tang R, et al. Among authors: tsai mk. Elife. 2020 Oct 7;9:e61080. doi: 10.7554/eLife.61080. Elife. 2020. PMID: 33025906 Free PMC article.
A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS-Driven Lung Cancer.
Cai H, Chew SK, Li C, Tsai MK, Andrejka L, Murray CW, Hughes NW, Shuldiner EG, Ashkin EL, Tang R, Hung KL, Chen LC, Lee SYC, Yousefi M, Lin WY, Kunder CA, Cong L, McFarland CD, Petrov DA, Swanton C, Winslow MM. Cai H, et al. Among authors: tsai mk. Cancer Discov. 2021 Jul;11(7):1754-1773. doi: 10.1158/2159-8290.CD-20-1325. Epub 2021 Feb 19. Cancer Discov. 2021. PMID: 33608386 Free PMC article.
LKB1 inactivation modulates chromatin accessibility to drive metastatic progression.
Pierce SE, Granja JM, Corces MR, Brady JJ, Tsai MK, Pierce AB, Tang R, Chu P, Feldser DM, Chang HY, Bassik MC, Greenleaf WJ, Winslow MM. Pierce SE, et al. Among authors: tsai mk. Nat Cell Biol. 2021 Aug;23(8):915-924. doi: 10.1038/s41556-021-00728-4. Epub 2021 Aug 2. Nat Cell Biol. 2021. PMID: 34341533 Free PMC article.
Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.
Yousefi M, Boross G, Weiss C, Murray CW, Hebert JD, Cai H, Ashkin EL, Karmakar S, Andrejka L, Chen L, Wang M, Tsai MK, Lin WY, Li C, Yakhchalian P, Colón CI, Chew SK, Chu P, Swanton C, Kunder CA, Petrov DA, Winslow MM. Yousefi M, et al. Among authors: tsai mk. Cancer Res. 2022 Apr 15;82(8):1589-1602. doi: 10.1158/0008-5472.CAN-22-0059. Cancer Res. 2022. PMID: 35425962 Free PMC article.
Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth.
Tang R, Shuldiner EG, Kelly M, Murray CW, Hebert JD, Andrejka L, Tsai MK, Hughes NW, Parker MI, Cai H, Li YC, Wahl GM, Dunbrack RL, Jackson PK, Petrov DA, Winslow MM. Tang R, et al. Among authors: tsai mk. Nat Cell Biol. 2023 Jan;25(1):159-169. doi: 10.1038/s41556-022-01049-w. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635501 Free PMC article.
Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages.
Gonzalez MA, Lu DR, Yousefi M, Kroll A, Lo CH, Briseño CG, Watson JEV, Novitskiy S, Arias V, Zhou H, Plata Stapper A, Tsai MK, Ashkin EL, Murray CW, Li CM, Winslow MM, Tarbell KV. Gonzalez MA, et al. Among authors: tsai mk. J Exp Med. 2023 Jun 5;220(6):e20221472. doi: 10.1084/jem.20221472. Epub 2023 Mar 30. J Exp Med. 2023. PMID: 36995340 Free PMC article.
Aging represses lung tumorigenesis and alters tumor suppression.
Shuldiner EG, Karmakar S, Tsai MK, Hebert JD, Tang YJ, Andrejka L, Wang M, Detrick CR, Cai H, Tang R, Petrov DA, Winslow MM. Shuldiner EG, et al. Among authors: tsai mk. bioRxiv [Preprint]. 2024 May 31:2024.05.28.596319. doi: 10.1101/2024.05.28.596319. bioRxiv. 2024. PMID: 38853826 Free PMC article. Preprint.
Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin Attenuates Sorafenib-Induced Myocardial Inflammation and Toxicity.
Liu CH, Ho YC, Lee WC, Huang CY, Lee YK, Hsieh CB, Huang NC, Wu CC, Nguyen NUN, Hsu CC, Chen CH, Chen YC, Huang WC, Lu YY, Fang CC, Chang YC, Chang CL, Tsai MK, Wen ZH, Li CZ, Li CC, Chuang PK, Yang SM, Chu TH, Huang SC. Liu CH, et al. Among authors: tsai mk. Environ Toxicol. 2024 Jun 17. doi: 10.1002/tox.24362. Online ahead of print. Environ Toxicol. 2024. PMID: 38884142
259 results