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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.
Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, Leander JD. Moskal JR, et al. Among authors: kroes ra. Expert Opin Investig Drugs. 2014 Feb;23(2):243-54. doi: 10.1517/13543784.2014.852536. Epub 2013 Nov 20. Expert Opin Investig Drugs. 2014. PMID: 24251380 Free PMC article. Review.
Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus.
Burgdorf J, Zhang XL, Colechio EM, Ghoreishi-Haack N, Gross A, Kroes RA, Stanton PK, Moskal JR. Burgdorf J, et al. Among authors: kroes ra. Int J Neuropsychopharmacol. 2015 Sep 15;19(2):pyv101. doi: 10.1093/ijnp/pyv101. Int J Neuropsychopharmacol. 2015. PMID: 26374350 Free PMC article.
IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity.
Burgdorf J, Colechio EM, Ghoreishi-Haack N, Gross AL, Rex CS, Zhang XL, Stanton PK, Kroes RA, Moskal JR. Burgdorf J, et al. Among authors: kroes ra. Int J Neuropsychopharmacol. 2017 Jun 1;20(6):476-484. doi: 10.1093/ijnp/pyx007. Int J Neuropsychopharmacol. 2017. PMID: 28158790 Free PMC article.
NMDAR activation regulates the daily rhythms of sleep and mood.
Burgdorf JS, Vitaterna MH, Olker CJ, Song EJ, Christian EP, Sørensen L, Turek FW, Madsen TM, Khan MA, Kroes RA, Moskal JR. Burgdorf JS, et al. Among authors: kroes ra. Sleep. 2019 Oct 9;42(10):zsz135. doi: 10.1093/sleep/zsz135. Sleep. 2019. PMID: 31504971 Free PMC article.
The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.
Burgdorf J, Zhang XL, Weiss C, Gross A, Boikess SR, Kroes RA, Khan MA, Burch RM, Rex CS, Disterhoft JF, Stanton PK, Moskal JR. Burgdorf J, et al. Among authors: kroes ra. Neuroscience. 2015 Nov 12;308:202-11. doi: 10.1016/j.neuroscience.2015.09.004. Epub 2015 Sep 4. Neuroscience. 2015. PMID: 26343295 Free PMC article.
63 results