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Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D. Cho JJ, et al. Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. Nat Commun. 2019. PMID: 30741923 Free PMC article.
BCL11B Regulates Arterial Stiffness and Related Target Organ Damage.
Valisno JAC, May J, Singh K, Helm EY, Venegas L, Budbazar E, Goodman JB, Nicholson CJ, Avram D, Cohen RA, Mitchell GF, Morgan KG, Seta F. Valisno JAC, et al. Among authors: helm ey. Circ Res. 2021 Mar 19;128(6):755-768. doi: 10.1161/CIRCRESAHA.120.316666. Epub 2021 Feb 3. Circ Res. 2021. PMID: 33530702 Free PMC article.
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.
Holmes TD, Pandey RV, Helm EY, Schlums H, Han H, Campbell TM, Drashansky TT, Chiang S, Wu CY, Tao C, Shoukier M, Tolosa E, Von Hardenberg S, Sun M, Klemann C, Marsh RA, Lau CM, Lin Y, Sun JC, Månsson R, Cichocki F, Avram D, Bryceson YT. Holmes TD, et al. Among authors: helm ey. Sci Immunol. 2021 Mar 12;6(57):eabc9801. doi: 10.1126/sciimmunol.abc9801. Sci Immunol. 2021. PMID: 33712472 Free PMC article.
BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program.
Drashansky TT, Helm EY, Curkovic N, Cooper J, Cheng P, Chen X, Gautam N, Meng L, Kwiatkowski AJ, Collins WO, Keselowsky BG, Sant'Angelo D, Huo Z, Zhang W, Zhou L, Avram D. Drashansky TT, et al. iScience. 2021 Mar 13;24(4):102307. doi: 10.1016/j.isci.2021.102307. eCollection 2021 Apr 23. iScience. 2021. PMID: 33870128 Free PMC article.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Kim MC, Borcherding N, Ahmed KK, Voigt AP, Vishwakarma A, Kolb R, Kluz PN, Pandey G, De U, Drashansky T, Helm EY, Zhang X, Gibson-Corley KN, Klesney-Tait J, Zhu Y, Lu J, Lu J, Huang X, Xiang H, Cheng J, Wang D, Wang Z, Tang J, Hu J, Wang Z, Liu H, Li M, Zhuang H, Avram D, Zhou D, Bacher R, Zheng SG, Wu X, Zakharia Y, Zhang W. Kim MC, et al. Nat Commun. 2021 Oct 1;12(1):5764. doi: 10.1038/s41467-021-26091-4. Nat Commun. 2021. PMID: 34599187 Free PMC article.
286 results