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Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver.
Sago CD, Lokugamage MP, Loughrey D, Lindsay KE, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Echeverri ES, Fitzgerald JP, Gan Z, Gamboa L, Paunovska K, Sanhueza CA, Hatit MZC, Finn MG, Santangelo PJ, Dahlman JE. Sago CD, et al. Among authors: gan z. Nat Biomed Eng. 2022 Feb;6(2):157-167. doi: 10.1038/s41551-022-00847-9. Epub 2022 Feb 21. Nat Biomed Eng. 2022. PMID: 35190679
Increased PIP3 activity blocks nanoparticle mRNA delivery.
Paunovska K, Da Silva Sanchez A, Foster MT, Loughrey D, Blanchard EL, Islam FZ, Gan Z, Mantalaris A, Santangelo PJ, Dahlman JE. Paunovska K, et al. Among authors: gan z. Sci Adv. 2020 Jul 22;6(30):eaba5672. doi: 10.1126/sciadv.aba5672. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32743074 Free PMC article.
1,273 results