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Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver.
Sawada T, Yamaura Y, Higuchi S, Imawaka H, Yamazaki H. Sawada T, et al. Among authors: imawaka h. Xenobiotica. 2020 May;50(5):526-535. doi: 10.1080/00498254.2019.1664791. Epub 2019 Sep 13. Xenobiotica. 2020. PMID: 31491346
A Human Immortalized Cell-Based Blood-Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug-Brain Permeability Studies.
Ito R, Umehara K, Suzuki S, Kitamura K, Nunoya KI, Yamaura Y, Imawaka H, Izumi S, Wakayama N, Komori T, Anzai N, Akita H, Furihata T. Ito R, et al. Among authors: imawaka h. Mol Pharm. 2019 Nov 4;16(11):4461-4471. doi: 10.1021/acs.molpharmaceut.9b00519. Epub 2019 Oct 15. Mol Pharm. 2019. PMID: 31573814
Species Difference in Hydrolysis of an Ester-Type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein.
Kono K, Nunoya KI, Nakamura Y, Bi J, Mukunoki A, Takeo T, Nakagata N, Maeda H, Yamaura Y, Imawaka H, Watanabe H, Maruyama T. Kono K, et al. Among authors: imawaka h. Mol Pharm. 2022 Sep 5;19(9):3450. doi: 10.1021/acs.molpharmaceut.2c00598. Epub 2022 Jul 28. Mol Pharm. 2022. PMID: 35900112 No abstract available.
19 results