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Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.
J Clin Pharmacol. 2020 Mar;60(3):312-323. doi: 10.1002/jcph.1523. Epub 2019 Sep 22.
J Clin Pharmacol. 2020.
PMID: 31542894
Trospium chloride is absorbed from two intestinal "absorption windows" with different permeability in healthy subjects.
Tadken T, Weiss M, Modess C, Wegner D, Roustom T, Neumeister C, Schwantes U, Schulz HU, Weitschies W, Siegmund W.
Tadken T, et al.
Int J Pharm. 2016 Dec 30;515(1-2):367-373. doi: 10.1016/j.ijpharm.2016.10.030. Epub 2016 Oct 17.
Int J Pharm. 2016.
PMID: 27765726
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Effects of the P-Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4-Way Crossover Drug-Drug Interaction Study in Healthy Subjects.
Abebe BT, Weiss M, Modess C, Roustom T, Tadken T, Wegner D, Schwantes U, Neumeister C, Schulz HU, Scheuch E, Siegmund W.
Abebe BT, et al. Among authors: tadken t.
J Clin Pharmacol. 2019 Oct;59(10):1319-1330. doi: 10.1002/jcph.1421. Epub 2019 Apr 11.
J Clin Pharmacol. 2019.
PMID: 30973998
Clinical Trial.
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