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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor.
Butler CR, Popiolek M, McAllister LA, LaChapelle EA, Kramer M, Beck EM, Mente S, Brodney MA, Brown M, Gilbert A, Helal C, Ogilvie K, Starr J, Uccello D, Grimwood S, Edgerton J, Garst-Orozko J, Kozak R, Lotarski S, Rossi A, Smith D, O'Connor R, Lazzaro J, Steppan C, Steyn SJ. Butler CR, et al. Among authors: o connor r. J Med Chem. 2024 Jun 18. doi: 10.1021/acs.jmedchem.4c00293. Online ahead of print. J Med Chem. 2024. PMID: 38888621
The single-cell opioid responses in the context of HIV (SCORCH) consortium.
Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H. Ament SA, et al. Among authors: o connor rm. Mol Psychiatry. 2024 Jun 15. doi: 10.1038/s41380-024-02620-7. Online ahead of print. Mol Psychiatry. 2024. PMID: 38879719 Review.
Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial.
Rodgers J, Cassidy S, Pelton M, Goodwin J, Wagnild J, Bhattarai N, Gordon I, Wilson C, Heslop P, Ogundimu E, O'Connor RC, Ramsay SE, Townsend E, Vale L. Rodgers J, et al. Among authors: o connor rc. EClinicalMedicine. 2024 Jun 1;73:102662. doi: 10.1016/j.eclinm.2024.102662. eCollection 2024 Jul. EClinicalMedicine. 2024. PMID: 38864075 Free PMC article.
A master regulator of opioid reward in the ventral prefrontal cortex.
Smith ACW, Ghoshal S, Centanni SW, Heyer MP, Corona A, Wills L, Andraka E, Lei Y, O'Connor RM, Caligiuri SPB, Khan S, Beaumont K, Sebra RP, Kieffer BL, Winder DG, Ishikawa M, Kenny PJ. Smith ACW, et al. Among authors: o connor rm. Science. 2024 Jun 7;384(6700):eadn0886. doi: 10.1126/science.adn0886. Epub 2024 Jun 7. Science. 2024. PMID: 38843332
2,220 results