Zhang X - Search Results

1

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.

Kroeck KG, Sacco MD, Smith EW, Zhang X, Shoun D, Akhtar A, Darch SE, Cohen F, Andrews LD, Knox JE, Chen Y. Kroeck KG, et al. Among authors: zhang x. Sci Rep. 2019 Oct 29;9(1):15450. doi: 10.1038/s41598-019-51844-z. Sci Rep. 2019. PMID: 31664082 Free PMC article.

2

Structures of Pseudomonas aeruginosa LpxA Reveal the Basis for Its Substrate Selectivity.

Smith EW, Zhang X, Behzadi C, Andrews LD, Cohen F, Chen Y. Smith EW, et al. Among authors: zhang x. Biochemistry. 2015 Sep 29;54(38):5937-48. doi: 10.1021/acs.biochem.5b00720. Epub 2015 Sep 18. Biochemistry. 2015. PMID: 26352800

3

Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).

Pemberton OA, Zhang X, Chen Y. Pemberton OA, et al. Among authors: zhang x. J Med Chem. 2017 Apr 27;60(8):3525-3530. doi: 10.1021/acs.jmedchem.7b00158. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28388065 Free PMC article.

4

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine.

Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Dempsey DR, et al. Among authors: zhang x. Sci Rep. 2017 Oct 18;7(1):13432. doi: 10.1038/s41598-017-13669-6. Sci Rep. 2017. PMID: 29044148 Free PMC article.

5

Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.

Pemberton OA, Zhang X, Nichols DA, DeFrees K, Jaishankar P, Bonnet R, Adams J, Shaw LN, Renslo AR, Chen Y. Pemberton OA, et al. Among authors: zhang x. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e02563-17. doi: 10.1128/AAC.02563-17. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29844038 Free PMC article.

6

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.

Torelli NJ, Akhtar A, DeFrees K, Jaishankar P, Pemberton OA, Zhang X, Johnson C, Renslo AR, Chen Y. Torelli NJ, et al. Among authors: zhang x. ACS Infect Dis. 2019 Jun 14;5(6):1013-1021. doi: 10.1021/acsinfecdis.9b00052. Epub 2019 Apr 15. ACS Infect Dis. 2019. PMID: 30942078

7

Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase.

Sacco MD, Kroeck KG, Kemp MT, Zhang X, Andrews LD, Chen Y. Sacco MD, et al. Among authors: zhang x. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01473-19. doi: 10.1128/AAC.01473-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31685462 Free PMC article.

8

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.

Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Ma C, et al. Among authors: zhang x. bioRxiv [Preprint]. 2020 Jan 6:2020.04.20.051581. doi: 10.1101/2020.04.20.051581. bioRxiv. 2020. Update in: Cell Res. 2020 Aug;30(8):678-692. doi: 10.1038/s41422-020-0356-z. PMID: 32511378 Free PMC article. Updated. Preprint.

9

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.

Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Ma C, et al. Among authors: zhang x. Cell Res. 2020 Aug;30(8):678-692. doi: 10.1038/s41422-020-0356-z. Epub 2020 Jun 15. Cell Res. 2020. PMID: 32541865 Free PMC article.

10

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M^pro and cathepsin L.

Sacco MD, Ma C, Lagarias P, Gao A, Townsend JA, Meng X, Dube P, Zhang X, Hu Y, Kitamura N, Hurst B, Tarbet B, Marty MT, Kolocouris A, Xiang Y, Chen Y, Wang J. Sacco MD, et al. Among authors: zhang x. bioRxiv [Preprint]. 2020 Jul 27:2020.07.27.223727. doi: 10.1101/2020.07.27.223727. bioRxiv. 2020. Update in: Sci Adv. 2020 Dec 9;6(50):eabe0751. doi: 10.1126/sciadv.abe0751. PMID: 32766590 Free PMC article. Updated. Preprint.

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