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Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes.
Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster BM, Worlock KB, Tvardovskiy A, Kunzelmann S, Herrero J, Bartke T, Gamblin SJ, Wilson JR, Jenner RG. Beltran M, et al. Among authors: tvardovskiy a. Nat Struct Mol Biol. 2019 Dec;26(12):1184-1186. doi: 10.1038/s41594-019-0341-8. Nat Struct Mol Biol. 2019. PMID: 31695189
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.
Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON, Helin K. Højfeldt JW, et al. Among authors: tvardovskiy a. Nat Struct Mol Biol. 2018 Mar;25(3):225-232. doi: 10.1038/s41594-018-0036-6. Epub 2018 Feb 26. Nat Struct Mol Biol. 2018. PMID: 29483650 Free PMC article.
G-tract RNA removes Polycomb repressive complex 2 from genes.
Beltran M, Tavares M, Justin N, Khandelwal G, Ambrose J, Foster BM, Worlock KB, Tvardovskiy A, Kunzelmann S, Herrero J, Bartke T, Gamblin SJ, Wilson JR, Jenner RG. Beltran M, et al. Among authors: tvardovskiy a. Nat Struct Mol Biol. 2019 Oct;26(10):899-909. doi: 10.1038/s41594-019-0293-z. Epub 2019 Sep 23. Nat Struct Mol Biol. 2019. PMID: 31548724 Free PMC article.
Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin.
Skalska L, Begley V, Beltran M, Lukauskas S, Khandelwal G, Faull P, Bhamra A, Tavares M, Wellman R, Tvardovskiy A, Foster BM, Ruiz de Los Mozos I, Herrero J, Surinova S, Snijders AP, Bartke T, Jenner RG. Skalska L, et al. Among authors: tvardovskiy a. Mol Cell. 2021 Jul 15;81(14):2944-2959.e10. doi: 10.1016/j.molcel.2021.05.026. Epub 2021 Jun 23. Mol Cell. 2021. PMID: 34166609 Free article.
Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability.
Gaggioli V, Lo CSY, Reverón-Gómez N, Jasencakova Z, Domenech H, Nguyen H, Sidoli S, Tvardovskiy A, Uruci S, Slotman JA, Chai Y, Gonçalves JGSCS, Manolika EM, Jensen ON, Wheeler D, Sridharan S, Chakrabarty S, Demmers J, Kanaar R, Groth A, Taneja N. Gaggioli V, et al. Among authors: tvardovskiy a. Nat Cell Biol. 2023 Jul;25(7):1017-1032. doi: 10.1038/s41556-023-01167-z. Epub 2023 Jul 6. Nat Cell Biol. 2023. PMID: 37414849 Free PMC article.
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.
Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM, Helin K. Mohammad F, et al. Among authors: tvardovskiy a. Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27. Nat Med. 2017. PMID: 28263309
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