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1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.
D'Ascenzio M, Secci D, Carradori S, Zara S, Guglielmi P, Cirilli R, Pierini M, Poli G, Tuccinardi T, Angeli A, Supuran CT. D'Ascenzio M, et al. Among authors: cirilli r. J Med Chem. 2020 Mar 12;63(5):2470-2488. doi: 10.1021/acs.jmedchem.9b01434. Epub 2020 Feb 4. J Med Chem. 2020. PMID: 31972093
Enantiomers of C(5)-chiral 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine oxidase.
Cirilli R, Ferretti R, Gallinella B, Turchetto L, Bolasco A, Secci D, Chimenti P, Pierini M, Fares V, Befani O, La Torre F. Cirilli R, et al. Chirality. 2004 Nov;16(9):625-36. doi: 10.1002/chir.20085. Chirality. 2004. PMID: 15382204
Analytical and semipreparative high performance liquid chromatography enantioseparation of new substituted 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazoles on polysaccharide-based chiral stationary phases in normal-phase, polar organic and reversed-phase conditions.
Cirilli R, Simonelli A, Ferretti R, Bolasco A, Chimenti P, Secci D, Maccioni E, La Torre F. Cirilli R, et al. J Chromatogr A. 2006 Jan 6;1101(1-2):198-203. doi: 10.1016/j.chroma.2005.10.003. Epub 2005 Oct 24. J Chromatogr A. 2006. PMID: 16246349
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives.
Chimenti F, Maccioni E, Secci D, Bolasco A, Chimenti P, Granese A, Befani O, Turini P, Alcaro S, Ortuso F, Cirilli R, La Torre F, Cardia MC, Distinto S. Chimenti F, et al. Among authors: cirilli r. J Med Chem. 2005 Nov 17;48(23):7113-22. doi: 10.1021/jm040903t. J Med Chem. 2005. PMID: 16279769
Synthesis, biological evaluation and 3D-QSAR of 1,3,5-trisubstituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase A inhibitors.
Chimenti F, Bolasco A, Manna F, Secci D, Chimenti P, Granese A, Befani O, Turini P, Cirilli R, La Torre F, Alcaro S, Ortuso F, Langer T. Chimenti F, et al. Among authors: cirilli r. Curr Med Chem. 2006;13(12):1411-28. doi: 10.2174/092986706776872907. Curr Med Chem. 2006. PMID: 16719786 Review.
1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.
La Regina G, D'Auria FD, Tafi A, Piscitelli F, Olla S, Caporuscio F, Nencioni L, Cirilli R, La Torre F, De Melo NR, Kelly SL, Lamb DC, Artico M, Botta M, Palamara AT, Silvestri R. La Regina G, et al. Among authors: cirilli r. J Med Chem. 2008 Jul 10;51(13):3841-55. doi: 10.1021/jm800009r. Epub 2008 Jun 5. J Med Chem. 2008. PMID: 18529046
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists.
Scapecchi S, Nesi M, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Manetti D, Martini E, Marucci G, Romanelli MN, Teodori E, Cirilli R. Scapecchi S, et al. Among authors: cirilli r. J Med Chem. 2008 Jul 10;51(13):3905-12. doi: 10.1021/jm800145d. Epub 2008 Jun 11. J Med Chem. 2008. PMID: 18543900
151 results