Itzhaki LS - Search Results

1

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.

Sharma K, Strizhak AV, Fowler E, Xu W, Chappell B, Sore HF, Galloway WRJD, Grayson MN, Lau YH, Itzhaki LS, Spring DR. Sharma K, et al. Among authors: itzhaki ls. ACS Omega. 2020 Jan 7;5(2):1157-1169. doi: 10.1021/acsomega.9b03459. eCollection 2020 Jan 21. ACS Omega. 2020. PMID: 31984273 Free PMC article.

2

Influence of Point Mutations on PR65 Conformational Adaptability: Insights from Nanoaperture Optical Tweezer Experiments and Molecular Simulations.

Bahar I, Banerjee A, Mathew S, Naqvi M, Yilmaz S, Zachoropoulou M, Doruker P, Kumita J, Yang SH, Gur M, Itzhaki L, Gordon R. Bahar I, et al. Res Sq [Preprint]. 2023 Nov 16:rs.3.rs-3599809. doi: 10.21203/rs.3.rs-3599809/v1. Res Sq. 2023. Update in: Sci Adv. 2024 May 31;10(22):eadn2208. doi: 10.1126/sciadv.adn2208. PMID: 38014259 Free PMC article. Updated. Preprint.

3

Single-molecule FRET reveals hidden complexity in a protein energy landscape.

Tsytlonok M, Ibrahim SM, Rowling PJE, Xu W, Ruedas-Rama MJ, Orte A, Klenerman D, Itzhaki LS. Tsytlonok M, et al. Among authors: itzhaki ls. Structure. 2015 Jan 6;23(1):190-198. doi: 10.1016/j.str.2014.10.023. Structure. 2015. PMID: 25565106 Free PMC article.

4

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.

Chattopadhyay A, O'Connor CJ, Zhang F, Galvagnion C, Galloway WR, Tan YS, Stokes JE, Rahman T, Verma C, Spring DR, Itzhaki LS. Chattopadhyay A, et al. Among authors: itzhaki ls. Sci Rep. 2016 Apr 5;6:23732. doi: 10.1038/srep23732. Sci Rep. 2016. PMID: 27046077 Free PMC article.

5

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

Wiedmann MM, Tan YS, Wu Y, Aibara S, Xu W, Sore HF, Verma CS, Itzhaki L, Stewart M, Brenton JD, Spring DR. Wiedmann MM, et al. Angew Chem Int Ed Engl. 2017 Jan 9;56(2):524-529. doi: 10.1002/anie.201609427. Epub 2016 Dec 5. Angew Chem Int Ed Engl. 2017. PMID: 27918136 Free PMC article.

6

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Xu W, et al. Among authors: itzhaki ls. J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7. J Am Chem Soc. 2017. PMID: 28084734 Free PMC article.

7

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.

Serrano JC, Sipthorp J, Xu W, Itzhaki LS, Ley SV. Serrano JC, et al. Among authors: itzhaki ls. Chembiochem. 2017 Jun 19;18(12):1066-1071. doi: 10.1002/cbic.201700075. Epub 2017 May 18. Chembiochem. 2017. PMID: 28388005 Free PMC article.

8

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.

Wu Y, Kaur A, Fowler E, Wiedmann MM, Young R, Galloway WRJD, Olsen L, Sore HF, Chattopadhyay A, Kwan TT, Xu W, Walsh SJ, de Andrade P, Janecek M, Arumugam S, Itzhaki LS, Lau YH, Spring DR. Wu Y, et al. Among authors: itzhaki ls. ACS Chem Biol. 2019 Mar 15;14(3):526-533. doi: 10.1021/acschembio.9b00063. Epub 2019 Feb 7. ACS Chem Biol. 2019. PMID: 30702850

9

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.

Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR. Charoenpattarapreeda J, et al. Chem Commun (Camb). 2019 Jul 14;55(55):7914-7917. doi: 10.1039/c9cc04022f. Epub 2019 Jun 21. Chem Commun (Camb). 2019. PMID: 31225847

10

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.

Sharma K, Strizhak AV, Fowler E, Wang X, Xu W, Hatt Jensen C, Wu Y, Sore HF, Lau YH, Hyvönen M, Itzhaki LS, Spring DR. Sharma K, et al. Among authors: itzhaki ls. Org Biomol Chem. 2019 Aug 28;17(34):8014-8018. doi: 10.1039/c9ob01745c. Org Biomol Chem. 2019. PMID: 31418442

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