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A randomized, phase 1, placebo-controlled trial of APG-157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor-associated microbes.
Basak SK, Bera A, Yoon AJ, Morselli M, Jeong C, Tosevska A, Dong TS, Eklund M, Russ E, Nasser H, Lagishetty V, Guo R, Sajed D, Mudgal S, Mehta P, Avila L, Srivastava M, Faull K, Jacobs J, Pellegrini M, Shin DS, Srivatsan ES, Wang MB. Basak SK, et al. Among authors: lagishetty v. Cancer. 2020 Apr 15;126(8):1668-1682. doi: 10.1002/cncr.32644. Epub 2020 Feb 5. Cancer. 2020. PMID: 32022261 Free article. Clinical Trial.
High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats.
Wang L, Jacobs JP, Lagishetty V, Yuan PQ, Wu SV, Million M, Reeve JR Jr, Pisegna JR, Taché Y. Wang L, et al. Among authors: lagishetty v. Am J Physiol Regul Integr Comp Physiol. 2017 Oct 1;313(4):R473-R486. doi: 10.1152/ajpregu.00105.2017. Epub 2017 Jul 19. Am J Physiol Regul Integr Comp Physiol. 2017. PMID: 28724546 Free PMC article.
Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study.
Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, Ayoub WS, Durazo F, Benhammou J, Enayati P, Elashoff D, Goodman MT, Pisegna J, Hussain S. Jacobs JP, et al. Among authors: lagishetty v. Hepatol Res. 2018 Dec;48(13):1108-1117. doi: 10.1111/hepr.13207. Epub 2018 Jul 30. Hepatol Res. 2018. PMID: 29923681 Free PMC article.
Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity.
Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka W, Rozengurt E, Jacobs JP, Eibl G. Dong TS, et al. Among authors: lagishetty v. Am J Physiol Gastrointest Liver Physiol. 2019 Dec 1;317(6):G763-G772. doi: 10.1152/ajpgi.00170.2019. Epub 2019 Sep 23. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31545922 Free PMC article.
Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis.
Hussain SK, Dong TS, Agopian V, Pisegna JR, Durazo FA, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Ayoub WS, Lagishetty V, Elashoff D, Goodman MT, Jacobs JP. Hussain SK, et al. Among authors: lagishetty v. Nutrients. 2020 May 13;12(5):1395. doi: 10.3390/nu12051395. Nutrients. 2020. PMID: 32414035 Free PMC article.
Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain-Gut-Microbiome Axis in Obese Women.
Dong TS, Gupta A, Jacobs JP, Lagishetty V, Gallagher E, Bhatt RR, Vora P, Osadchiy V, Stains J, Balioukova A, Chen Y, Dutson E, Mayer EA, Sanmiguel C. Dong TS, et al. Among authors: lagishetty v. Nutrients. 2020 Sep 24;12(10):2924. doi: 10.3390/nu12102924. Nutrients. 2020. PMID: 32987837 Free PMC article.
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