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T Cell Dysfunction in Cancer.
Thommen DS, Schumacher TN. Thommen DS, et al. Cancer Cell. 2018 Apr 9;33(4):547-562. doi: 10.1016/j.ccell.2018.03.012. Cancer Cell. 2018. PMID: 29634943 Free PMC article. Review.
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schill C, Hess C, Savic Prince S, Wiese M, Lardinois D, Ho PC, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A. Thommen DS, et al. Nat Med. 2018 Jul;24(7):994-1004. doi: 10.1038/s41591-018-0057-z. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892065 Free PMC article.
Long-distance modulation of bystander tumor cells by CD8+ T cell-secreted IFNγ.
Hoekstra ME, Bornes L, Dijkgraaf FE, Philips D, Pardieck IN, Toebes M, Thommen DS, van Rheenen J, Schumacher TNM. Hoekstra ME, et al. Among authors: thommen ds. Nat Cancer. 2020 Mar;1(3):291-301. doi: 10.1038/s43018-020-0036-4. Epub 2020 Mar 9. Nat Cancer. 2020. PMID: 32566933 Free PMC article.
Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy.
Pelly VS, Moeini A, Roelofsen LM, Bonavita E, Bell CR, Hutton C, Blanco-Gomez A, Banyard A, Bromley CP, Flanagan E, Chiang SC, Jørgensen C, Schumacher TN, Thommen DS, Zelenay S. Pelly VS, et al. Among authors: thommen ds. Cancer Discov. 2021 Oct;11(10):2602-2619. doi: 10.1158/2159-8290.CD-20-1815. Epub 2021 May 24. Cancer Discov. 2021. PMID: 34031121 Free PMC article.
An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer.
Voabil P, de Bruijn M, Roelofsen LM, Hendriks SH, Brokamp S, van den Braber M, Broeks A, Sanders J, Herzig P, Zippelius A, Blank CU, Hartemink KJ, Monkhorst K, Haanen JBAG, Schumacher TN, Thommen DS. Voabil P, et al. Among authors: thommen ds. Nat Med. 2021 Jul;27(7):1250-1261. doi: 10.1038/s41591-021-01398-3. Epub 2021 Jul 8. Nat Med. 2021. PMID: 34239134
Single-cell analysis of regions of interest (SCARI) using a photosensitive tag.
van der Leun AM, Hoekstra ME, Reinalda L, Scheele CLGJ, Toebes M, van de Graaff MJ, Chen LYY, Li H, Bercovich A, Lubling Y, David E, Thommen DS, Tanay A, van Rheenen J, Amit I, van Kasteren SI, Schumacher TN. van der Leun AM, et al. Among authors: thommen ds. Nat Chem Biol. 2021 Nov;17(11):1139-1147. doi: 10.1038/s41589-021-00839-x. Epub 2021 Sep 9. Nat Chem Biol. 2021. PMID: 34504322 Free PMC article.
Tertiary lymphoid structures in cancer.
Schumacher TN, Thommen DS. Schumacher TN, et al. Among authors: thommen ds. Science. 2022 Jan 7;375(6576):eabf9419. doi: 10.1126/science.abf9419. Epub 2022 Jan 7. Science. 2022. PMID: 34990248 Review.
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