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Group II metabotropic glutamate receptors and schizophrenia.
Moreno JL, Sealfon SC, González-Maeso J. Moreno JL, et al. Cell Mol Life Sci. 2009 Dec;66(23):3777-85. doi: 10.1007/s00018-009-0130-3. Epub 2009 Aug 26. Cell Mol Life Sci. 2009. PMID: 19707855 Free PMC article. Review.
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. Fribourg M, et al. Cell. 2011 Nov 23;147(5):1011-23. doi: 10.1016/j.cell.2011.09.055. Cell. 2011. PMID: 22118459 Free PMC article.
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. Kurita M, et al. Nat Neurosci. 2012 Sep;15(9):1245-54. doi: 10.1038/nn.3181. Epub 2012 Aug 5. Nat Neurosci. 2012. PMID: 22864611 Free PMC article.
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function.
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. Moreno JL, et al. J Biol Chem. 2012 Dec 28;287(53):44301-19. doi: 10.1074/jbc.M112.413161. Epub 2012 Nov 5. J Biol Chem. 2012. PMID: 23129762 Free PMC article.
114 results