Haigis KM - Search Results

1

Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.

Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Zambetti NA, et al. Among authors: haigis km. Blood. 2020 May 14;135(20):1772-1782. doi: 10.1182/blood.2019003530. Blood. 2020. PMID: 32219446 Free PMC article.

2

Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis.

Van Egeren D, Kohli K, Warner JL, Bedard PL, Riely G, Lepisto E, Schrag D, LeNoue-Newton M, Catalano P, Kehl KL, Michor F; AACR Project GENIE Consortium represented by Shawn Sweeney. Van Egeren D, et al. Sci Rep. 2022 Nov 9;12(1):19055. doi: 10.1038/s41598-022-21448-1. Sci Rep. 2022. PMID: 36351964 Free PMC article.

3

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Haigis KM, et al. Among authors: haigis mc. Nat Genet. 2008 May;40(5):600-8. doi: 10.1038/ng.115. Epub 2008 Mar 30. Nat Genet. 2008. PMID: 18372904 Free PMC article.

4

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Li Q, et al. Among authors: haigis km. Blood. 2011 Feb 10;117(6):2022-32. doi: 10.1182/blood-2010-04-280750. Epub 2010 Dec 16. Blood. 2011. PMID: 21163920 Free PMC article.

5

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. Xu J, et al. Among authors: haigis km. Blood. 2012 Jan 26;119(4):1032-5. doi: 10.1182/blood-2011-06-358960. Epub 2011 Dec 5. Blood. 2012. PMID: 22144181 Free PMC article.

6

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Xu J, et al. Among authors: haigis km. Cancer Discov. 2013 Sep;3(9):993-1001. doi: 10.1158/2159-8290.CD-13-0096. Epub 2013 Jun 3. Cancer Discov. 2013. PMID: 23733505 Free PMC article.

7

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Burgess MR, et al. Among authors: haigis km. Blood. 2014 Dec 18;124(26):3947-55. doi: 10.1182/blood-2014-05-574582. Epub 2014 Oct 31. Blood. 2014. PMID: 25361812 Free PMC article.

8

KRAS Alleles: The Devil Is in the Detail.

Haigis KM. Haigis KM. Trends Cancer. 2017 Oct;3(10):686-697. doi: 10.1016/j.trecan.2017.08.006. Epub 2017 Sep 12. Trends Cancer. 2017. PMID: 28958387 Free PMC article. Review.

9

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

Bender RH, Haigis KM, Gutmann DH. Bender RH, et al. Among authors: haigis km. Stem Cells. 2015 Jun;33(6):1998-2010. doi: 10.1002/stem.1990. Stem Cells. 2015. PMID: 25788415 Free PMC article.

10

Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells.

Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Gierut JJ, et al. Among authors: haigis km. Stem Cell Res. 2015 Jul;15(1):165-71. doi: 10.1016/j.scr.2015.06.003. Epub 2015 Jun 10. Stem Cell Res. 2015. PMID: 26079371 Free PMC article.

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