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α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis.
Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog EL. Ishikawa G, et al. Among authors: sun y, sun h. Am J Physiol Lung Cell Mol Physiol. 2023 May 1;324(5):L639-L651. doi: 10.1152/ajplung.00119.2022. Epub 2023 Jan 17. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36648147 Free PMC article.
Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis.
Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. Zhou Y, et al. Among authors: sun h. Sci Transl Med. 2014 Jun 11;6(240):240ra76. doi: 10.1126/scitranslmed.3007096. Sci Transl Med. 2014. PMID: 24920662 Free PMC article.
Fibroblast engraftment in the decellularized mouse lung occurs via a β1-integrin-dependent, FAK-dependent pathway that is mediated by ERK and opposed by AKT.
Sun H, Calle E, Chen X, Mathur A, Zhu Y, Mendez J, Zhao L, Niklason L, Peng X, Peng H, Herzog EL. Sun H, et al. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15;306(6):L463-75. doi: 10.1152/ajplung.00100.2013. Epub 2013 Dec 13. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24337923 Free PMC article.
Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis.
Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Gao R, et al. Among authors: sun h. J Clin Invest. 2021 Jan 4;131(1):e136542. doi: 10.1172/JCI136542. J Clin Invest. 2021. PMID: 33393489 Free PMC article.
Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.
Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo-Maya JD, Kaminski N, Hu X, Pan H, Ryu C, Osafo-Addo A, Homer RJ, Feghali-Bostwick C, Fares WH, Gulati M, Hu B, Lee CG, Elias JA, Herzog EL. Peng X, et al. Among authors: sun h. FASEB J. 2016 Dec;30(12):4056-4070. doi: 10.1096/fj.201600373R. Epub 2016 Sep 8. FASEB J. 2016. PMID: 27609773 Free PMC article.
These data demonstrate the previously unrecognized observation that PLXNC1 deficiency permits Syt7-mediated macrophage migration and enhances mammalian lung fibrosis.-Peng, X., Moore, M., Mathur, A., Zhou, Y., Sun, H., Gan, Y., Herazo-Maya, J. D., Kaminski, N., Hu, …
These data demonstrate the previously unrecognized observation that PLXNC1 deficiency permits Syt7-mediated macrophage migration and enhance …
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