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In Human Autoimmunity, a Substantial Component of the B Cell Repertoire Consists of Polyclonal, Barely Mutated IgG+ve B Cells.
Front Immunol. 2020 Mar 20;11:395. doi: 10.3389/fimmu.2020.00395. eCollection 2020.
Front Immunol. 2020.
PMID: 32265907
Free PMC article.
Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation.
Silver J, Zuo T, Chaudhary N, Kumari R, Tong P, Giguere S, Granato A, Donthula R, Devereaux C, Wesemann DR.
Silver J, et al.
J Exp Med. 2018 Jan 2;215(1):77-90. doi: 10.1084/jem.20171022. Epub 2017 Dec 15.
J Exp Med. 2018.
PMID: 29247044
Free PMC article.
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DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers.
Janssen E, Tohme M, Butts J, Giguere S, Sage PT, Velázquez FE, Kam C, Milin E, Das M, Sobh A, Al-Tamemi S, Luscinskas FW, Batista F, Geha RS.
Janssen E, et al.
JCI Insight. 2020 Aug 6;5(15):e134508. doi: 10.1172/jci.insight.134508.
JCI Insight. 2020.
PMID: 32573493
Free PMC article.
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Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.
Wang X, Ray R, Kratochvil S, Melzi E, Lin YC, Giguere S, Xu L, Warner J, Cheon D, Liguori A, Groschel B, Phelps N, Adachi Y, Tingle R, Wu L, Crotty S, Kirsch KH, Nair U, Schief WR, Batista FD.
Wang X, et al.
EMBO J. 2021 Jan 15;40(2):e105926. doi: 10.15252/embj.2020105926. Epub 2020 Dec 1.
EMBO J. 2021.
PMID: 33258500
Free PMC article.
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Affinity gaps among B cells in germinal centers drive the selection of MPER precursors.
Ray R, Schiffner T, Wang X, Yan Y, Rantalainen K, Lee CD, Parikh S, Reyes RA, Dale GA, Lin YC, Pecetta S, Giguere S, Swanson O, Kratochvil S, Melzi E, Phung I, Madungwe L, Kalyuzhniy O, Warner J, Weldon SR, Tingle R, Lamperti E, Kirsch KH, Phelps N, Georgeson E, Adachi Y, Kubitz M, Nair U, Crotty S, Wilson IA, Schief WR, Batista FD.
Ray R, et al.
Nat Immunol. 2024 Jun;25(6):1083-1096. doi: 10.1038/s41590-024-01844-7. Epub 2024 May 30.
Nat Immunol. 2024.
PMID: 38816616
Free PMC article.
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The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression.
Giguère SS, Guise AJ, Jean Beltran PM, Joshi PM, Greco TM, Quach OL, Kong J, Cristea IM.
Giguère SS, et al.
Mol Cell Proteomics. 2016 Mar;15(3):791-809. doi: 10.1074/mcp.M115.054619. Epub 2015 Dec 9.
Mol Cell Proteomics. 2016.
PMID: 26657080
Free PMC article.
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A Functional Proteomics Perspective of DBC1 as a Regulator of Transcription.
Joshi P, Quach OL, Giguere SS, Cristea IM.
Joshi P, et al.
J Proteomics Bioinform. 2013 Apr 18;Suppl 2:002.
J Proteomics Bioinform. 2013.
PMID: 24273392
Free PMC article.
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Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand.
Giguère S, Wang X, Huber S, Xu L, Warner J, Weldon SR, Hu J, Phan QA, Tumang K, Prum T, Ma D, Kirsch KH, Nair U, Dedon P, Batista FD.
Giguère S, et al.
Science. 2024 Jan 12;383(6679):205-211. doi: 10.1126/science.adi1763. Epub 2024 Jan 11.
Science. 2024.
PMID: 38207021
Free PMC article.
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