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Targeting the pregnane X receptor using microbial metabolite mimicry.
Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, Naren AP, Murray IA, Perdew GH, Brtko J, Toporova L, Schön A, Wallace BD, Walton WG, Redinbo MR, Sun K, Beck A, Kortagere S, Neary MC, Chandran A, Vishveshwara S, Cavalluzzi MM, Lentini G, Cui JY, Gu H, March JC, Chatterjee S, Matson A, Wright D, Flannigan KL, Hirota SA, Sartor RB, Mani S. Dvořák Z, et al. Among authors: vyhlidalova b. EMBO Mol Med. 2020 Apr 7;12(4):e11621. doi: 10.15252/emmm.201911621. Epub 2020 Mar 10. EMBO Mol Med. 2020. PMID: 32153125 Free PMC article.
Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice.
Grycová A, Joo H, Maier V, Illés P, Vyhlídalová B, Poulíková K, Sládeková L, Nádvorník P, Vrzal R, Zemánková L, Pečinková P, Poruba M, Zapletalová I, Večeřa R, Anzenbacher P, Ehrmann J, Ondra P, Jung JW, Mani S, Dvořák Z. Grycová A, et al. Among authors: vyhlidalova b. J Med Chem. 2022 May 12;65(9):6859-6868. doi: 10.1021/acs.jmedchem.2c00208. Epub 2022 Apr 13. J Med Chem. 2022. PMID: 35416668
Inhibition of Aryl Hydrocarbon Receptor (AhR) Expression Disrupts Cell Proliferation and Alters Energy Metabolism and Fatty Acid Synthesis in Colon Cancer Cells.
Karasová M, Procházková J, Tylichová Z, Fedr R, Ciganek M, Machala M, Dvořák Z, Vyhlídalová B, Zůvalová I, Ehrmann J, Bouchal J, Andrysík Z, Vondráček J. Karasová M, et al. Among authors: vyhlidalova b. Cancers (Basel). 2022 Aug 31;14(17):4245. doi: 10.3390/cancers14174245. Cancers (Basel). 2022. PMID: 36077780 Free PMC article.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Ondrová K, Zůvalová I, Vyhlídalová B, Krasulová K, Miková E, Vrzal R, Nádvorník P, Nepal B, Kortagere S, Kopečná M, Kopečný D, Šebela M, Rastinejad F, Pu H, Soural M, Rolfes KM, Haarmann-Stemmann T, Li H, Mani S, Dvořák Z. Ondrová K, et al. Among authors: vyhlidalova b. Nat Commun. 2023 May 11;14(1):2728. doi: 10.1038/s41467-023-38478-6. Nat Commun. 2023. PMID: 37169746 Free PMC article.
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