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Enhancing the activity of membrane remodeling epsin-peptide by trimerization.
Hsu WY, Masuda T, Afonin S, Sakai T, Arafiles JVV, Kawano K, Hirose H, Imanishi M, Ulrich AS, Futaki S. Hsu WY, et al. Among authors: sakai t. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127190. doi: 10.1016/j.bmcl.2020.127190. Epub 2020 Apr 15. Bioorg Med Chem Lett. 2020. PMID: 32317210
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.
Hirata K, Kotoku M, Seki N, Maeba T, Maeda K, Hirashima S, Sakai T, Obika S, Hori A, Hase Y, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Asahina K, Aratsu Y, Kamada M, Adachi T, Noguchi M, Doi S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Hashimoto H, Shiozaki M. Hirata K, et al. Among authors: sakai t. ACS Med Chem Lett. 2015 Nov 4;7(1):23-7. doi: 10.1021/acsmedchemlett.5b00253. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819660 Free PMC article.
Concise SAR Exploration Based on the "Head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds.
Noji S, Seki N, Maeba T, Sakai T, Watanabe E, Maeda K, Fukushima K, Noguchi T, Ogawa K, Toyonaga Y, Negoro T, Kawasaki H, Shiozaki M. Noji S, et al. Among authors: sakai t. ACS Med Chem Lett. 2016 Aug 3;7(10):919-923. doi: 10.1021/acsmedchemlett.6b00232. eCollection 2016 Oct 13. ACS Med Chem Lett. 2016. PMID: 27774129 Free PMC article.
Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: sakai t. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624
Objective physical function declines in the absence of subjective physical complaints among patients with amnestic mild cognitive impairments and mild alzheimer's disease.
Fujisawa C, Umegaki H, Sugimoto T, Nakashima H, Komiya H, Watanabe K, Nagae M, Yamada Y, Tajima T, Sakai T, Sakurai T. Fujisawa C, et al. Among authors: sakai t. Eur Geriatr Med. 2024 Jun 14. doi: 10.1007/s41999-024-01005-x. Online ahead of print. Eur Geriatr Med. 2024. PMID: 38877373
5,611 results