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Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura.
Roose E, Schelpe AS, Tellier E, Sinkovits G, Joly BS, Dekimpe C, Kaplanski G, Le Besnerais M, Mancini I, Falter T, Von Auer C, Feys HB, Reti M, Rossmann H, Vandenbulcke A, Pareyn I, Voorberg J, Greinacher A, Benhamou Y, Deckmyn H, Fijnheer R, Prohászka Z, Peyvandi F, Lämmle B, Coppo P, De Meyer SF, Veyradier A, Vanhoorelbeke K. Roose E, et al. Among authors: vandenbulcke a. Blood. 2020 Jul 16;136(3):353-361. doi: 10.1182/blood.2019004221. Blood. 2020. PMID: 32356859 Free article. Clinical Trial.
The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice.
De Cock E, Hermans C, De Raeymaecker J, De Ceunynck K, De Maeyer B, Vandeputte N, Vandenbulcke A, Deckmyn H, Rottensteiner H, De Maeyer M, De Meyer SF, Vanhoorelbeke K. De Cock E, et al. Among authors: vandenbulcke a. J Thromb Haemost. 2015 Feb;13(2):283-92. doi: 10.1111/jth.12804. Epub 2015 Jan 17. J Thromb Haemost. 2015. PMID: 25442981 Free article.
Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.
Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. Deforche L, et al. Among authors: vandenbulcke a. J Thromb Haemost. 2015 Nov;13(11):2063-75. doi: 10.1111/jth.13149. Epub 2015 Oct 20. J Thromb Haemost. 2015. PMID: 26391536 Free PMC article.
ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.
Denorme F, Langhauser F, Desender L, Vandenbulcke A, Rottensteiner H, Plaimauer B, François O, Andersson T, Deckmyn H, Scheiflinger F, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF. Denorme F, et al. Among authors: vandenbulcke a. Blood. 2016 May 12;127(19):2337-45. doi: 10.1182/blood-2015-08-662650. Epub 2016 Feb 29. Blood. 2016. PMID: 26929275 Free article.
Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.
Deforche L, Tersteeg C, Roose E, Vandenbulcke A, Vandeputte N, Pareyn I, De Cock E, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. Deforche L, et al. Among authors: vandenbulcke a. PLoS One. 2016 Aug 1;11(8):e0160388. doi: 10.1371/journal.pone.0160388. eCollection 2016. PLoS One. 2016. PMID: 27479501 Free PMC article.
N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura.
Tersteeg C, Roodt J, Van Rensburg WJ, Dekimpe C, Vandeputte N, Pareyn I, Vandenbulcke A, Plaimauer B, Lamprecht S, Deckmyn H, Lopez JA, De Meyer SF, Vanhoorelbeke K. Tersteeg C, et al. Among authors: vandenbulcke a. Blood. 2017 Feb 23;129(8):1030-1038. doi: 10.1182/blood-2016-09-738856. Epub 2016 Dec 23. Blood. 2017. PMID: 28011677 Free article.
43 results