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Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells.
Litchfield LM, Boehnke K, Brahmachary M, Mur C, Bi C, Stephens JR, Sauder JM, Gutiérrez SM, McNulty AM, Ye XS, Wu W, Lallena MJ, Gong X, Merzoug FF, Jansen VM, Buchanan SG. Litchfield LM, et al. Among authors: sauder jm. Oncotarget. 2020 Apr 28;11(17):1478-1492. doi: 10.18632/oncotarget.27539. eCollection 2020 Apr 28. Oncotarget. 2020. PMID: 32391118 Free PMC article.
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Buchanan SG, Hendle J, Lee PS, Smith CR, Bounaud PY, Jessen KA, Tang CM, Huser NH, Felce JD, Froning KJ, Peterman MC, Aubol BE, Gessert SF, Sauder JM, Schwinn KD, Russell M, Rooney IA, Adams J, Leon BC, Do TH, Blaney JM, Sprengeler PA, Thompson DA, Smyth L, Pelletier LA, Atwell S, Holme K, Wasserman SR, Emtage S, Burley SK, Reich SH. Buchanan SG, et al. Among authors: sauder jm. Mol Cancer Ther. 2009 Dec;8(12):3181-90. doi: 10.1158/1535-7163.MCT-09-0477. Mol Cancer Ther. 2009. PMID: 19934279
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Lewis HA, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, Rajashankar KR, Rutter ME, Sauder JM, Shriver S, Thibodeau PH, Thomas PJ, Zhang M, Zhao X, Emtage S. Lewis HA, et al. Among authors: sauder jm. EMBO J. 2004 Jan 28;23(2):282-93. doi: 10.1038/sj.emboj.7600040. Epub 2003 Dec 18. EMBO J. 2004. PMID: 14685259 Free PMC article.
Structural analysis of a set of proteins resulting from a bacterial genomics project.
Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ. Badger J, et al. Among authors: sauder jm. Proteins. 2005 Sep 1;60(4):787-96. doi: 10.1002/prot.20541. Proteins. 2005. PMID: 16021622
Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure.
Lewis HA, Zhao X, Wang C, Sauder JM, Rooney I, Noland BW, Lorimer D, Kearins MC, Conners K, Condon B, Maloney PC, Guggino WB, Hunt JF, Emtage S. Lewis HA, et al. Among authors: sauder jm. J Biol Chem. 2005 Jan 14;280(2):1346-53. doi: 10.1074/jbc.M410968200. Epub 2004 Nov 3. J Biol Chem. 2005. PMID: 15528182 Free article.
Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.
Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK. Sampathkumar P, et al. Among authors: sauder jm. J Mol Biol. 2010 Apr 9;397(4):883-92. doi: 10.1016/j.jmb.2010.02.017. Epub 2010 Feb 13. J Mol Biol. 2010. PMID: 20156452 Free PMC article.
61 results