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A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in Its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors.
Xing H, Andrud KW, Soti F, Rouchaud A, Jahn SC, Lu Z, Cho YH, Habibi S, Corsino P, Slavov S, Rocca JR, Lindstrom JM, Lukas RJ, Kem WR. Xing H, et al. Among authors: soti f. Mol Pharmacol. 2020 Aug;98(2):168-180. doi: 10.1124/mol.119.118786. Epub 2020 May 30. Mol Pharmacol. 2020. PMID: 32474444 Free PMC article.
Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration.
Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Kem WR, et al. Among authors: soti f. Mol Pharmacol. 2004 Jan;65(1):56-67. doi: 10.1124/mol.65.1.56. Mol Pharmacol. 2004. PMID: 14722237
Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia.
Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R. Olincy A, et al. Among authors: soti f. Arch Gen Psychiatry. 2006 Jun;63(6):630-8. doi: 10.1001/archpsyc.63.6.630. Arch Gen Psychiatry. 2006. PMID: 16754836 Clinical Trial.
Initial phase 2 trial of a nicotinic agonist in schizophrenia.
Freedman R, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, Allensworth D, Guzman-Bonilla A, Clement B, Ball MP, Kutnick J, Pender V, Martin LF, Stevens KE, Wagner BD, Zerbe GO, Soti F, Kem WR. Freedman R, et al. Among authors: soti f. Am J Psychiatry. 2008 Aug;165(8):1040-7. doi: 10.1176/appi.ajp.2008.07071135. Epub 2008 Apr 1. Am J Psychiatry. 2008. PMID: 18381905 Free PMC article. Clinical Trial.
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