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Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop.
Aykul S, Corpina RA, Goebel EJ, Cunanan CJ, Dimitriou A, Kim HJ, Zhang Q, Rafique A, Leidich R, Wang X, McClain J, Jimenez J, Nannuru KC, Rothman NJ, Lees-Shepard JB, Martinez-Hackert E, Murphy AJ, Thompson TB, Economides AN, Idone V. Aykul S, et al. Among authors: rothman nj. Elife. 2020 Jun 9;9:e54582. doi: 10.7554/eLife.54582. Elife. 2020. PMID: 32515349 Free PMC article.
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.
Aykul S, Huang L, Wang L, Das NM, Reisman S, Ray Y, Zhang Q, Rothman N, Nannuru KC, Kamat V, Brydges S, Troncone L, Johnsen L, Yu PB, Fazio S, Lees-Shepard J, Schutz K, Murphy AJ, Economides AN, Idone V, Hatsell SJ. Aykul S, et al. J Clin Invest. 2022 Jun 15;132(12):e153792. doi: 10.1172/JCI153792. J Clin Invest. 2022. PMID: 35511419 Free PMC article.
Skeletal phenotype amelioration in mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development.
Hwang-Wong E, Amar G, Das N, Zhang X, Aaron N, Gale K, Rothman N, Fante M, Baik A, Bhargava A, Fricker A, McAlister M, Rabinowitz J, Lees-Shepard J, Nannuru K, Economides AN, Cygnar KD. Hwang-Wong E, et al. JCI Insight. 2023 Nov 8;8(21):e171312. doi: 10.1172/jci.insight.171312. JCI Insight. 2023. PMID: 37751300 Free PMC article.
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes.
Mosialou I, Shikhel S, Luo N, Petropoulou PI, Panitsas K, Bisikirska B, Rothman NJ, Tenta R, Cariou B, Wargny M, Sornay-Rendu E, Nickolas T, Rubin M, Confavreux CB, Kousteni S. Mosialou I, et al. Among authors: rothman nj. J Exp Med. 2020 Oct 5;217(10):e20191261. doi: 10.1084/jem.20191261. J Exp Med. 2020. PMID: 32639539 Free PMC article.
Correction: IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination.
Kratchmarov R, Nish SA, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Klein U, Reiner SL. Kratchmarov R, et al. Among authors: rothman nj. Immunohorizons. 2018 Jan 2;2(1):12-13. doi: 10.4049/immunohorizons.1700072. Immunohorizons. 2018. PMID: 31022688 Free article. No abstract available.
IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination.
Kratchmarov R, Nish SA, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Klein U, Reiner SL. Kratchmarov R, et al. Among authors: rothman nj. Immunohorizons. 2017 Sep 1;1(7):156-161. doi: 10.4049/immunohorizons.1700012. Immunohorizons. 2017. PMID: 28944344 Free PMC article.
15 results