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Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J Med Chem. 2020 Jul 9;63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. Epub 2020 Jun 25.
J Med Chem. 2020.
PMID: 32530624
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.
Martin RE, Aebi JD, Hornsperger B, Krebs HJ, Kuhn B, Kuglstatter A, Alker AM, Märki HP, Müller S, Burger D, Ottaviani G, Riboulet W, Verry P, Tan X, Amrein K, Mayweg AV.
Martin RE, et al. Among authors: hornsperger b.
J Med Chem. 2015 Oct 22;58(20):8054-65. doi: 10.1021/acs.jmedchem.5b00851. Epub 2015 Oct 2.
J Med Chem. 2015.
PMID: 26403853
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A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.
Kemble AM, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, Heer D, Wittwer M, Engelhardt B, Grether U, Collin L.
Kemble AM, et al. Among authors: hornsperger b.
PLoS One. 2022 Sep 9;17(9):e0268590. doi: 10.1371/journal.pone.0268590. eCollection 2022.
PLoS One. 2022.
PMID: 36084029
Free PMC article.
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Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold.
He Y, Gobbi LC, Herde AM, Rombach D, Ritter M, Kuhn B, Wittwer MB, Heer D, Hornsperger B, Bell C, O'Hara F, Benz J, Honer M, Keller C, Collin L, Richter H, Schibli R, Grether U, Mu L.
He Y, et al. Among authors: hornsperger b.
Nucl Med Biol. 2022 May-Jun;108-109:24-32. doi: 10.1016/j.nucmedbio.2022.02.002. Epub 2022 Feb 23.
Nucl Med Biol. 2022.
PMID: 35248850
Free article.
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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.
Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, Cabrera AC, Chen CY, Hoflack JC, Kam-Thong T, Schmucki R, Badi L, Flint N, Ghiani ZE, Delobel F, Stucki C, Gromo G, Einhaus A, Hornsperger B, Golling S, Siebourg-Polster J, Gerber F, Bohrmann B, Futter C, Dunkley T, Hiller S, Schilling O, Enzmann V, Fauser S, Plodinec M, Iacone R.
Melo E, et al. Among authors: hornsperger b.
EBioMedicine. 2018 Jan;27:258-274. doi: 10.1016/j.ebiom.2017.12.011. Epub 2017 Dec 13.
EBioMedicine. 2018.
PMID: 29269042
Free PMC article.
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