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Beyond the cyclopropyl ring formation: fungal Aj_EasH catalyzes asymmetric hydroxylation of ergot alkaloids.
An C, Zhu F, Yao Y, Zhang K, Wang W, Zhang J, Wei G, Xia Y, Gao Q, Gao SS. An C, et al. Appl Microbiol Biotechnol. 2022 Apr;106(8):2981-2991. doi: 10.1007/s00253-022-11892-4. Epub 2022 Apr 7. Appl Microbiol Biotechnol. 2022. PMID: 35389067
Herein we reconstituted the biosynthesis of 4 in vitro from prechanoclavine (1) for the first time. Additionally, an unexpected activity of asymmetric hydroxylation at the C-4 position of EA compound festuclavine (5) for Aj_EasH was revealed. ...
Herein we reconstituted the biosynthesis of 4 in vitro from prechanoclavine (1) for the first time. Additionally, an unexpected activ …
1,569 results