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The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.
Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H251-H261. doi: 10.1152/ajpheart.00038.2020. Epub 2020 Jun 19.
Am J Physiol Heart Circ Physiol. 2020.
PMID: 32559136
Free article.
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243.
Kemp JM, Whittaker DG, Venkateshappa R, Pang Z, Johal R, Sergeev V, Tibbits GF, Mirams GR, Claydon TW.
Kemp JM, et al. Among authors: venkateshappa r.
J Gen Physiol. 2021 Oct 4;153(10):e202112923. doi: 10.1085/jgp.202112923. Epub 2021 Aug 16.
J Gen Physiol. 2021.
PMID: 34398210
Free PMC article.
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Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.
Simpson KE, Venkateshappa R, Pang ZK, Faizi S, Tibbits GF, Claydon TW.
Simpson KE, et al. Among authors: venkateshappa r.
Front Physiol. 2021 Jan 15;11:624129. doi: 10.3389/fphys.2020.624129. eCollection 2020.
Front Physiol. 2021.
PMID: 33519527
Free PMC article.
Review.
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Ion channel model reduction using manifold boundaries.
Whittaker DG, Wang J, Shuttleworth JG, Venkateshappa R, Kemp JM, Claydon TW, Mirams GR.
Whittaker DG, et al. Among authors: venkateshappa r.
J R Soc Interface. 2022 Aug;19(193):20220193. doi: 10.1098/rsif.2022.0193. Epub 2022 Aug 10.
J R Soc Interface. 2022.
PMID: 35946166
Free PMC article.
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CRISPR-Cas9-mediated Precise Knock-in Edits in Zebrafish Hearts.
Simpson KE, Faizi S, Venkateshappa R, Yip M, Johal R, Poburko D, Cheng YM, Hunter D, Lin E, Tibbits GF, Claydon TW.
Simpson KE, et al. Among authors: venkateshappa r.
J Vis Exp. 2022 Sep 13;(187). doi: 10.3791/64209.
J Vis Exp. 2022.
PMID: 36190280
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Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations.
Zhang M, Venkateshappa R, Li A, Fowler MB, Telli ML, Wu JC.
Zhang M, et al. Among authors: venkateshappa r.
Stem Cell Res. 2023 Dec;73:103246. doi: 10.1016/j.scr.2023.103246. Epub 2023 Nov 6.
Stem Cell Res. 2023.
PMID: 37951143
Free PMC article.
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Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Venkateshappa R, Hunter DV, Muralidharan P, Nagalingam RS, Huen G, Faizi S, Luthra S, Lin E, Cheng YM, Hughes J, Khelifi R, Dhunna DP, Johal R, Sergeev V, Shafaattalab S, Julian LM, Poburko DT, Laksman Z, Tibbits GF, Claydon TW.
Venkateshappa R, et al.
Cardiovasc Res. 2023 Nov 25;119(15):2522-2535. doi: 10.1093/cvr/cvad155.
Cardiovasc Res. 2023.
PMID: 37739930
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