Thomas DD - Search Results

1

Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells.

Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas DD, Langen R, Sachs JN. Lo CH, et al. Among authors: thomas dd. ACS Chem Neurosci. 2020 Aug 5;11(15):2286-2295. doi: 10.1021/acschemneuro.0c00226. Epub 2020 Jul 7. ACS Chem Neurosci. 2020. PMID: 32568514

2

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized.

Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. Valley CC, et al. Among authors: thomas dd. J Biol Chem. 2012 Jun 15;287(25):21265-78. doi: 10.1074/jbc.M111.306480. Epub 2012 Apr 10. J Biol Chem. 2012. PMID: 22496450 Free PMC article.

3

High-throughput FRET assay yields allosteric SERCA activators.

Cornea RL, Gruber SJ, Lockamy EL, Muretta JM, Jin D, Chen J, Dahl R, Bartfai T, Zsebo KM, Gillispie GD, Thomas DD. Cornea RL, et al. Among authors: thomas dd. J Biomol Screen. 2013 Jan;18(1):97-107. doi: 10.1177/1087057112456878. Epub 2012 Aug 24. J Biomol Screen. 2013. PMID: 22923787 Free PMC article.

4

Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells.

Gruber SJ, Cornea RL, Li J, Peterson KC, Schaaf TM, Gillispie GD, Dahl R, Zsebo KM, Robia SL, Thomas DD. Gruber SJ, et al. Among authors: thomas dd. J Biomol Screen. 2014 Feb;19(2):215-22. doi: 10.1177/1087057113510740. J Biomol Screen. 2014. PMID: 24436077 Free PMC article.

5

Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation.

Lewis AK, James ZM, McCaffrey JE, Braun AR, Karim CB, Thomas DD, Sachs JN. Lewis AK, et al. Among authors: thomas dd. Biophys J. 2014 Mar 18;106(6):L21-4. doi: 10.1016/j.bpj.2014.01.044. Biophys J. 2014. PMID: 24655519 Free PMC article.

6

Oxidation increases the strength of the methionine-aromatic interaction.

Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, Hinderliter A, Sachs JN. Lewis AK, et al. Among authors: thomas dd. Nat Chem Biol. 2016 Oct;12(10):860-6. doi: 10.1038/nchembio.2159. Epub 2016 Aug 22. Nat Chem Biol. 2016. PMID: 27547920 Free PMC article.

7

A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.

Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW. Kraft TE, et al. Among authors: thomas dd. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. doi: 10.1128/AAC.00218-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27736766 Free PMC article.

8

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels.

Rebbeck RT, Essawy MM, Nitu FR, Grant BD, Gillispie GD, Thomas DD, Bers DM, Cornea RL. Rebbeck RT, et al. Among authors: thomas dd. SLAS Discov. 2017 Feb;22(2):176-186. doi: 10.1177/1087057116674312. Epub 2016 Oct 22. SLAS Discov. 2017. PMID: 27760856 Free PMC article.

9

Spectral Unmixing Plate Reader: High-Throughput, High-Precision FRET Assays in Living Cells.

Schaaf TM, Peterson KC, Grant BD, Thomas DD, Gillispie GD. Schaaf TM, et al. Among authors: thomas dd. SLAS Discov. 2017 Mar;22(3):250-261. doi: 10.1177/1087057116679637. Epub 2016 Nov 23. SLAS Discov. 2017. PMID: 27879398 Free PMC article.

10

High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA.

Schaaf TM, Peterson KC, Grant BD, Bawaskar P, Yuen S, Li J, Muretta JM, Gillispie GD, Thomas DD. Schaaf TM, et al. Among authors: thomas dd. SLAS Discov. 2017 Mar;22(3):262-273. doi: 10.1177/1087057116680151. Epub 2016 Dec 13. SLAS Discov. 2017. PMID: 27899691 Free PMC article.

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