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Activation of Adenosine Monophosphate-Activated Protein Kinase Reduces the Onset of Diet-Induced Hepatocellular Carcinoma in Mice.
Schmoll D, Ziegler N, Viollet B, Foretz M, Even PC, Azzout-Marniche D, Nygaard Madsen A, Illemann M, Mandrup K, Feigh M, Czech J, Glombik H, Olsen JA, Hennerici W, Steinmeyer K, Elvert R, Castañeda TR, Kannt A. Schmoll D, et al. Among authors: czech j. Hepatol Commun. 2020 May 15;4(7):1056-1072. doi: 10.1002/hep4.1508. eCollection 2020 Jul. Hepatol Commun. 2020. PMID: 32626837 Free PMC article.
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Elvert R, Czech J, Pfenninger A, Rudolph C, Schreuder H, Chandrasekar DV, Mane VS, Birudukota S, Shaik S, Zope BR, Burri RR, Anand NN, Thakur MK, Singh M, Parveen R, Kandan S, Mullangi R, Yura T, Gosu R, Ruf S, Dhakshinamoorthy S. Kannt A, et al. Among authors: czech j. Sci Rep. 2018 Feb 26;8(1):3660. doi: 10.1038/s41598-018-22081-7. Sci Rep. 2018. PMID: 29483571 Free PMC article.
Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).
Schreuder H, Liesum A, Lönze P, Stump H, Hoffmann H, Schiell M, Kurz M, Toti L, Bauer A, Kallus C, Klemke-Jahn C, Czech J, Kramer D, Enke H, Niedermeyer THJ, Morrison V, Kumar V, Brönstrup M. Schreuder H, et al. Among authors: czech j. Sci Rep. 2016 Sep 8;6:32958. doi: 10.1038/srep32958. Sci Rep. 2016. PMID: 27604544 Free PMC article.
Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes.
Nazaré M, Matter H, Will DW, Wagner M, Urmann M, Czech J, Schreuder H, Bauer A, Ritter K, Wehner V. Nazaré M, et al. Among authors: czech j. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):905-11. doi: 10.1002/anie.201107091. Epub 2011 Dec 21. Angew Chem Int Ed Engl. 2012. PMID: 22190348 No abstract available.
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.
Nazaré M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V. Nazaré M, et al. Among authors: czech j. J Med Chem. 2005 Jul 14;48(14):4511-25. doi: 10.1021/jm0490540. J Med Chem. 2005. PMID: 15999990
86 results