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Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.
Sharkey LM, Sandoval-Pistorius SS, Moore SJ, Gerson JE, Komlo R, Fischer S, Negron-Rios KY, Crowley EV, Padron F, Patel R, Murphy GG, Paulson HL. Sharkey LM, et al. Among authors: murphy gg. Neurobiol Dis. 2020 Sep;143:105016. doi: 10.1016/j.nbd.2020.105016. Epub 2020 Jul 10. Neurobiol Dis. 2020. PMID: 32653673 Free PMC article.
Identification of a neurovascular signaling pathway regulating seizures in mice.
Fredriksson L, Stevenson TK, Su EJ, Ragsdale M, Moore S, Craciun S, Schielke GP, Murphy GG, Lawrence DA. Fredriksson L, et al. Among authors: murphy gg. Ann Clin Transl Neurol. 2015 Jul;2(7):722-38. doi: 10.1002/acn3.209. Epub 2015 May 1. Ann Clin Transl Neurol. 2015. PMID: 26273685 Free PMC article.
Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder.
Jones JM, Dionne L, Dell'Orco J, Parent R, Krueger JN, Cheng X, Dib-Hajj SD, Bunton-Stasyshyn RK, Sharkey LM, Dowling JJ, Murphy GG, Shakkottai VG, Shrager P, Meisler MH. Jones JM, et al. Among authors: murphy gg. Neurobiol Dis. 2016 May;89:36-45. doi: 10.1016/j.nbd.2016.01.018. Epub 2016 Jan 22. Neurobiol Dis. 2016. PMID: 26807988 Free PMC article.
A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.
Ramani B, Harris GM, Huang R, Seki T, Murphy GG, Carmo Costa MD, Fischer S, Saunders TL, Xia G, McEachin RC, Paulson HL. Ramani B, et al. Among authors: murphy gg. Hum Mol Genet. 2017 Aug 15;26(16):3232-3233. doi: 10.1093/hmg/ddx176. Hum Mol Genet. 2017. PMID: 28605434 Free PMC article. No abstract available.
90 results