Wyatt PG - Search Results

1

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity.

Thomas MG, De Rycker M, Wall RJ, Spinks D, Epemolu O, Manthri S, Norval S, Osuna-Cabello M, Patterson S, Riley J, Simeons FRC, Stojanovski L, Thomas J, Thompson S, Naylor C, Fiandor JM, Wyatt PG, Marco M, Wyllie S, Read KD, Miles TJ, Gilbert IH. Thomas MG, et al. Among authors: wyatt pg. J Med Chem. 2020 Sep 10;63(17):9523-9539. doi: 10.1021/acs.jmedchem.0c00705. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32663005 Free PMC article.

2

Benzophenone derivatives: a novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

Wyatt PG, Bethell RC, Cammack N, Charon D, Dodic N, Dumaitre B, Evans DN, Green DV, Hopewell PL, Humber DC, et al. Wyatt PG, et al. J Med Chem. 1995 May 12;38(10):1657-65. doi: 10.1021/jm00010a010. J Med Chem. 1995. PMID: 7538590

3

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.

Smith PW, Sollis SL, Howes PD, Cherry PC, Starkey ID, Cobley KN, Weston H, Scicinski J, Merritt A, Whittington A, Wyatt P, Taylor N, Green D, Bethell R, Madar S, Fenton RJ, Morley PJ, Pateman T, Beresford A. Smith PW, et al. J Med Chem. 1998 Mar 12;41(6):787-97. doi: 10.1021/jm970374b. J Med Chem. 1998. PMID: 9526555

4

Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.

Wyatt PG, Allen MJ, Chilcott J, Gardner CJ, Livermore DG, Mordaunt JE, Nerozzi F, Patel M, Perren MJ, Weingarten GG, Shabbir S, Woollard PM, Zhou P. Wyatt PG, et al. Bioorg Med Chem Lett. 2002 May 20;12(10):1405-11. doi: 10.1016/s0960-894x(02)00160-9. Bioorg Med Chem Lett. 2002. PMID: 11992787

5

2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR.

Wyatt PG, Allen MJ, Borthwick AD, Davies DE, Exall AM, Hatley RJ, Irving WR, Livermore DG, Miller ND, Nerozzi F, Sollis SL, Szardenings AK. Wyatt PG, et al. Bioorg Med Chem Lett. 2005 May 16;15(10):2579-82. doi: 10.1016/j.bmcl.2005.03.045. Bioorg Med Chem Lett. 2005. PMID: 15863320

6

Target assessment for antiparasitic drug discovery.

Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Frearson JA, et al. Among authors: wyatt pg. Trends Parasitol. 2007 Dec;23(12):589-95. doi: 10.1016/j.pt.2007.08.019. Epub 2007 Oct 24. Trends Parasitol. 2007. PMID: 17962072 Free PMC article. Review.

7

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.

Brenk R, Schipani A, James D, Krasowski A, Gilbert IH, Frearson J, Wyatt PG. Brenk R, et al. Among authors: wyatt pg. ChemMedChem. 2008 Mar;3(3):435-44. doi: 10.1002/cmdc.200700139. ChemMedChem. 2008. PMID: 18064617 Free PMC article.

8

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: wyatt pg. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

9

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Patterson S, Jones DC, Shanks EJ, Frearson JA, Gilbert IH, Wyatt PG, Fairlamb AH. Patterson S, et al. Among authors: wyatt pg. ChemMedChem. 2009 Aug;4(8):1341-53. doi: 10.1002/cmdc.200900098. ChemMedChem. 2009. PMID: 19557802 Free PMC article.

10

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

Torrie LS, Wyllie S, Spinks D, Oza SL, Thompson S, Harrison JR, Gilbert IH, Wyatt PG, Fairlamb AH, Frearson JA. Torrie LS, et al. Among authors: wyatt pg. J Biol Chem. 2009 Dec 25;284(52):36137-36145. doi: 10.1074/jbc.M109.045336. Epub 2009 Oct 14. J Biol Chem. 2009. PMID: 19828449 Free PMC article.

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