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Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline.
Lantero Rodriguez J, Karikari TK, Suárez-Calvet M, Troakes C, King A, Emersic A, Aarsland D, Hye A, Zetterberg H, Blennow K, Ashton NJ. Lantero Rodriguez J, et al. Among authors: hye a. Acta Neuropathol. 2020 Sep;140(3):267-278. doi: 10.1007/s00401-020-02195-x. Epub 2020 Jul 27. Acta Neuropathol. 2020. PMID: 32720099 Free PMC article.
Plasma proteins predict conversion to dementia from prodromal disease.
Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S. Hye A, et al. Alzheimers Dement. 2014 Nov;10(6):799-807.e2. doi: 10.1016/j.jalz.2014.05.1749. Epub 2014 Jul 8. Alzheimers Dement. 2014. PMID: 25012867 Free PMC article.
Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins.
Voyle N, Kim M, Proitsi P, Ashton NJ, Baird AL, Bazenet C, Hye A, Westwood S, Chung R, Ward M, Rabinovici GD, Lovestone S, Breen G, Legido-Quigley C, Dobson RJ, Kiddle SJ; Alzheimer's Disease Neuroimaging Initiative. Voyle N, et al. Among authors: hye a. Transl Psychiatry. 2016 Jan 26;6(1):e719. doi: 10.1038/tp.2015.205. Transl Psychiatry. 2016. PMID: 26812040 Free PMC article.
Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.
Westwood S, Leoni E, Hye A, Lynham S, Khondoker MR, Ashton NJ, Kiddle SJ, Baird AL, Sainz-Fuertes R, Leung R, Graf J, Hehir CT, Baker D, Cereda C, Bazenet C, Ward M, Thambisetty M, Lovestone S. Westwood S, et al. Among authors: hye a. J Alzheimers Dis. 2016 Mar 29;52(2):561-72. doi: 10.3233/JAD-151155. J Alzheimers Dis. 2016. PMID: 27031486 Free PMC article.
Blood protein predictors of brain amyloid for enrichment in clinical trials?
Ashton NJ, Kiddle SJ, Graf J, Ward M, Baird AL, Hye A, Westwood S, Wong KV, Dobson RJ, Rabinovici GD, Miller BL, Rosen HJ, Torres A, Zhang Z, Thurfjell L, Covin A, Hehir CT, Baker D, Bazenet C, Lovestone S; AIBL Research Group. Ashton NJ, et al. Among authors: hye a. Alzheimers Dement (Amst). 2015 Mar 29;1(1):48-60. doi: 10.1016/j.dadm.2014.11.005. eCollection 2015 Mar. Alzheimers Dement (Amst). 2015. PMID: 27239491 Free PMC article.
Update on biomarkers for amyloid pathology in Alzheimer's disease.
Ashton NJ, Schöll M, Heurling K, Gkanatsiou E, Portelius E, Höglund K, Brinkmalm G, Hye A, Blennow K, Zetterberg H. Ashton NJ, et al. Among authors: hye a. Biomark Med. 2018 Jul;12(7):799-812. doi: 10.2217/bmm-2017-0433. Epub 2018 Jun 15. Biomark Med. 2018. PMID: 29902934 Review.
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