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Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity.
Camacho RC, You S, D'Aquino KE, Li W, Wang Y, Gunnet J, Littrell J, Qi JS, Kang L, Jian W, MacDonald M, Tat T, Steiner D, Zhang YM, Lanter J, Patch R, Zhang R, Li J, Edavettal S, Edwards W, Dinh T, Wang LY, Connor J, Hunter M, Chi E, Swanson RV, Leonard JN, Case MA. Camacho RC, et al. Among authors: gunnet j. MAbs. 2020 Jan-Dec;12(1):1794687. doi: 10.1080/19420862.2020.1794687. MAbs. 2020. PMID: 32744157 Free PMC article.
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.
Zhang X, Cai C, Winters M, Wells M, Wall M, Lanter J, Sui Z, Ma J, Novack A, Nashashibi I, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Zhang X, et al. Among authors: gunnet j. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3272-3278. doi: 10.1016/j.bmcl.2017.06.028. Epub 2017 Jun 12. Bioorg Med Chem Lett. 2017. PMID: 28642104
Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.
Winters MP, Sui Z, Wall M, Wang Y, Gunnet J, Leonard J, Hua H, Yan W, Suckow A, Bell A, Clapper W, Jenkinson C, Haug P, Koudriakova T, Huebert N, Murray WV. Winters MP, et al. Among authors: gunnet j. Bioorg Med Chem Lett. 2018 Mar 1;28(5):841-846. doi: 10.1016/j.bmcl.2018.02.013. Epub 2018 Feb 8. Bioorg Med Chem Lett. 2018. PMID: 29456108
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.
Zhang X, Cai C, Sui Z, Macielag M, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Zhang X, et al. Among authors: gunnet j. ACS Med Chem Lett. 2017 Jul 27;8(9):947-952. doi: 10.1021/acsmedchemlett.7b00233. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947942 Free PMC article.
Erratum to "Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes" Bioorg. Med. Chem. Lett. 28 (2018) [841-846].
Winters MP, Sui Z, Wall M, Wang Y, Gunnet J, Leonard J, Hua H, Yan W, Suckow A, Bell A, Clapper W, Jenkinson C, Haug P, Koudriakova T, Huebert N, Murray WV. Winters MP, et al. Among authors: gunnet j. Bioorg Med Chem Lett. 2018 May 15;28(9):1676-1678. doi: 10.1016/j.bmcl.2018.03.053. Epub 2018 Mar 28. Bioorg Med Chem Lett. 2018. PMID: 29605534 No abstract available.
Discovery of a novel potent GPR40 full agonist.
Meegalla SK, Huang H, Martin T, Xu J, Zhao S, Liu J, Hall M, Gunnet J, Wang Y, Rady B, Silva J, Otieno M, Arnoult E, Paul Lee S, Pocai A, Player MR. Meegalla SK, et al. Among authors: gunnet j. Bioorg Med Chem Lett. 2018 Feb 15;28(4):720-726. doi: 10.1016/j.bmcl.2018.01.013. Epub 2018 Jan 12. Bioorg Med Chem Lett. 2018. PMID: 29366647
51 results