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mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism.
Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjörnsson M, Marciano R, Scharov K, Planque M, Vriens K, Christen S, Funk CM, Hassiepen C, Kahler A, Heider B, Picard D, Lim JKM, Stefanski A, Bendrin K, Vargas-Toscano A, Kahlert UD, Stühler K, Remke M, Elkabets M, Grünewald TGP, Reichert AS, Fendt SM, Schulze A, Reifenberger G, Rotblat B, Leprivier G. Levy T, et al. Among authors: remke m. Nat Commun. 2024 May 14;15(1):4083. doi: 10.1038/s41467-024-48386-y. Nat Commun. 2024. PMID: 38744825 Free PMC article.
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
Kocher D, Cao L, Guiho R, Langhammer M, Lai YL, Becker P, Hamdi H, Friedel D, Selt F, Vonhören D, Zaman J, Valinciute G, Herter S, Picard D, Rettenmeier J, Maass KK, Pajtler KW, Remke M, von Deimling A, Pusch S, Pfister SM, Oehme I, Jones DTW, Halbach S, Brummer T, Martinez-Barbera JP, Witt O, Milde T, Sigaud R. Kocher D, et al. Among authors: remke m. J Neurooncol. 2024 Apr 17. doi: 10.1007/s11060-024-04672-9. Online ahead of print. J Neurooncol. 2024. PMID: 38630384
Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia.
Blumel L, Bernardi F, Picard D, Diaz JT, Jepsen VH, Hasselmann R, Schliehe-Diecks J, Bartl J, Qin N, Bornhauser B, Bhatia S, Marovka B, Marsaud V, Dingli F, Loew D, Stanulla M, Bourqin JP, Borkhardt A, Remke M, Ayrault O, Fischer U. Blumel L, et al. Among authors: remke m. Haematologica. 2024 Feb 29. doi: 10.3324/haematol.2023.283928. Online ahead of print. Haematologica. 2024. PMID: 38426288 Free article.
The development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H.
Mehjardi NZ, Kessler J, Sanin AY, Picard D, Westhoff P, Nickel AC, Uhlmann C, Shi W, Steiger HJ, Remke M, Fischer I, Vordermark D, Croner RS, Kahlert UD. Mehjardi NZ, et al. Among authors: remke m. Cell Death Discov. 2023 Dec 12;9(1):452. doi: 10.1038/s41420-023-01747-w. Cell Death Discov. 2023. PMID: 38086797 Free PMC article.
Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells.
Vogt M, Dienstbier N, Schliehe-Diecks J, Scharov K, Tu JW, Gebing P, Hogenkamp J, Bilen BS, Furlan S, Picard D, Remke M, Yasin L, Bickel D, Kalia M, Iacoangeli A, Lenz T, Stühler K, Pandyra AA, Hauer J, Fischer U, Wagener R, Borkhardt A, Bhatia S. Vogt M, et al. Among authors: remke m. Cell Death Dis. 2023 Dec 6;14(12):799. doi: 10.1038/s41419-023-06337-3. Cell Death Dis. 2023. PMID: 38057328 Free PMC article.
Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
Schoof M, Godbole S, Albert TK, Dottermusch M, Walter C, Ballast A, Qin N, Olivera MB, Göbel C, Neyazi S, Holdhof D, Kresbach C, Peter LS, Epplen GD, Thaden V, Spohn M, Blattner-Johnson M, Modemann F, Mynarek M, Rutkowski S, Sill M, Varghese J, Afflerbach AK, Eckhardt A, Münter D, Verma A, Struve N, Jones DTW, Remke M, Neumann JE, Kerl K, Schüller U. Schoof M, et al. Among authors: remke m. Nat Commun. 2023 Nov 24;14(1):7717. doi: 10.1038/s41467-023-43564-w. Nat Commun. 2023. PMID: 38001143 Free PMC article.
197 results