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Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis.
J Mol Med (Berl). 2020 Oct;98(10):1385-1395. doi: 10.1007/s00109-020-01958-z. Epub 2020 Aug 18.
J Mol Med (Berl). 2020.
PMID: 32808093
Free PMC article.
Review.
Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis.
Lechner K, Mott S, Al-Saifi R, Knipfer L, Wirtz S, Atreya R, Vieth M, Rath T, Fraass T, Winter Z, August A, Luban J, Zimmermann VS, Weigmann B, Neurath MF.
Lechner K, et al.
Gastroenterology. 2021 Oct;161(4):1270-1287.e19. doi: 10.1053/j.gastro.2021.06.072. Epub 2021 Jul 3.
Gastroenterology. 2021.
PMID: 34224738
Free article.
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Small but powerful: will nanoparticles be the future state-of-the-art therapy for IBD?
Lechner K, Zeeshan M, Noack M, Ali H, Neurath MF, Weigmann B.
Lechner K, et al.
Expert Opin Drug Deliv. 2022 Mar;19(3):235-245. doi: 10.1080/17425247.2022.2043847. Epub 2022 Mar 3.
Expert Opin Drug Deliv. 2022.
PMID: 35184617
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The JAK1/3 inhibitor tofacitinib suppresses T cell homing and activation in chronic intestinal inflammation.
Gerlach K, Lechner K, Popp V, Offensperger L, Zundler S, Wiendl M, Becker E, Atreya R, Rath T, Neurath MF, Weigmann B.
Gerlach K, et al.
J Crohns Colitis. 2020 Aug 18:jjaa162. doi: 10.1093/ecco-jcc/jjaa162. Online ahead of print.
J Crohns Colitis. 2020.
PMID: 32808031
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Label-Free Characterization and Quantification of Mucosal Inflammation in Common Murine Colitis Models With Multiphoton Imaging.
Kreiss L, Thoma OM, Lemire S, Lechner K, Carlé B, Dilipkumar A, Kunert T, Scheibe K, Heichler C, Merten AL, Weigmann B, Neufert C, Hildner K, Vieth M, Neurath MF, Friedrich O, Schürmann S, Waldner MJ.
Kreiss L, et al.
Inflamm Bowel Dis. 2022 Nov 2;28(11):1637-1646. doi: 10.1093/ibd/izac114.
Inflamm Bowel Dis. 2022.
PMID: 35699622
Free PMC article.
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NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.
Radulovic K, Ayata CK, Mak'Anyengo R, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, Niess JH.
Radulovic K, et al.
J Immunol. 2019 Jul 15;203(2):544-556. doi: 10.4049/jimmunol.1800938. Epub 2019 May 31.
J Immunol. 2019.
PMID: 31152078
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