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UNCAN.eu: Toward a European Federated Cancer Research Data Hub.
Boutros M, Baumann M, Bigas A, Chaabane L, Guérin J, Habermann JK, Jobard A, Pelicci PG, Stegle O, Tonon G, Valencia A, Winkler EC, Blanc P, De Maria R, Medema RH, Nagy P, Tabernero J, Solary E. Boutros M, et al. Among authors: bigas a. Cancer Discov. 2024 Jan 12;14(1):30-35. doi: 10.1158/2159-8290.CD-23-1111. Cancer Discov. 2024. PMID: 38213296 Free PMC article.
Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling.
Estupiñán Ó, Rey V, Tornín J, Murillo D, Gallego B, Huergo C, Blanco-Lorenzo V, Victoria González M, Rodríguez A, Moris F, González J, Ayllón V, Ramos-Mejía V, Bigas A, Rodríguez R. Estupiñán Ó, et al. Among authors: bigas a. Biomed Pharmacother. 2023 Jun;162:114627. doi: 10.1016/j.biopha.2023.114627. Epub 2023 Apr 3. Biomed Pharmacother. 2023. PMID: 37018985 Free article.
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.
Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L. Mulero MC, et al. Among authors: bigas a. Cancer Cell. 2013 Aug 12;24(2):151-66. doi: 10.1016/j.ccr.2013.06.003. Epub 2013 Jul 11. Cancer Cell. 2013. PMID: 23850221 Free PMC article.
Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A. Porcheri C, et al. Among authors: bigas a. EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9. EMBO J. 2020. PMID: 32149421 Free PMC article.
Notch Signaling in HSC Emergence: When, Why and How.
Thambyrajah R, Bigas A. Thambyrajah R, et al. Among authors: bigas a. Cells. 2022 Jan 21;11(3):358. doi: 10.3390/cells11030358. Cells. 2022. PMID: 35159166 Free PMC article. Review.
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.
García-Hernández V, Arambilet D, Guillén Y, Lobo-Jarne T, Maqueda M, Gekas C, González J, Iglesias A, Vega-García N, Sentís I, Trincado JL, Márquez-López I, Heyn H, Camós M, Espinosa L, Bigas A. García-Hernández V, et al. Among authors: bigas a. EMBO Mol Med. 2023 Feb 8;15(2):e16554. doi: 10.15252/emmm.202216554. Epub 2023 Jan 4. EMBO Mol Med. 2023. PMID: 36597789 Free PMC article.
Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.
Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guillén Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang X, Calero-Nieto FJ, Esteller M, Florian MC, Porta E, Benedito R, Göttgens B, Lacaud G, Espinosa L, Bigas A. Thambyrajah R, et al. Among authors: bigas a. Nat Commun. 2024 Feb 21;15(1):1604. doi: 10.1038/s41467-024-45716-y. Nat Commun. 2024. PMID: 38383534 Free PMC article.
IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development.
Thambyrajah R, Maqueda M, Fadlullah MZ, Proffitt M, Neo WH, Guillén Y, Casado-Pelaez M, Herrero-Molinero P, Brujas C, Castelluccio N, González J, Iglesias A, Marruecos L, Ruiz-Herguido C, Esteller M, Mereu E, Lacaud G, Espinosa L, Bigas A. Thambyrajah R, et al. Among authors: bigas a. Nat Commun. 2024 Jun 1;15(1):4673. doi: 10.1038/s41467-024-48854-5. Nat Commun. 2024. PMID: 38824124 Free PMC article.
Hematopoietic stem cells: to be or Notch to be.
Bigas A, Espinosa L. Bigas A, et al. Blood. 2012 Apr 5;119(14):3226-35. doi: 10.1182/blood-2011-10-355826. Epub 2012 Feb 3. Blood. 2012. PMID: 22308291 Free article. Review.
122 results