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Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC. Lee TH, et al. Among authors: fang y. Nat Commun. 2020 Aug 26;11(1):4254. doi: 10.1038/s41467-020-18047-x. Nat Commun. 2020. PMID: 32848143 Free PMC article.
Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.
Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y. Huang RT, et al. Among authors: fang y. Am J Respir Crit Care Med. 2017 Mar 1;195(5):639-651. doi: 10.1164/rccm.201604-0668OC. Am J Respir Crit Care Med. 2017. PMID: 27855271 Free PMC article.
Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.
Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I. Le Master E, et al. Among authors: fang y. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):64-75. doi: 10.1161/ATVBAHA.117.309907. Epub 2017 Oct 12. Arterioscler Thromb Vasc Biol. 2018. PMID: 29025707 Free PMC article.
NOTCH1 is a mechanosensor in adult arteries.
Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. Mack JJ, et al. Among authors: fang y. Nat Commun. 2017 Nov 20;8(1):1620. doi: 10.1038/s41467-017-01741-8. Nat Commun. 2017. PMID: 29158473 Free PMC article.
Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
Shih YC, Chen CL, Zhang Y, Mellor RL, Kanter EM, Fang Y, Wang HC, Hung CT, Nong JY, Chen HJ, Lee TH, Tseng YS, Chen CN, Wu CC, Lin SL, Yamada KA, Nerbonne JM, Yang KC. Shih YC, et al. Among authors: fang y. Circ Res. 2018 Apr 13;122(8):1052-1068. doi: 10.1161/CIRCRESAHA.117.312130. Epub 2018 Mar 13. Circ Res. 2018. PMID: 29535165 Free PMC article.
Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Krause MD, et al. Among authors: fang y. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11349-E11358. doi: 10.1073/pnas.1810568115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429326 Free PMC article.
SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy.
Lee TH, Wu D, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. Lee TH, et al. Among authors: fang y. bioRxiv [Preprint]. 2021 Jan 18:2021.01.15.426691. doi: 10.1101/2021.01.15.426691. bioRxiv. 2021. Update in: Am J Respir Cell Mol Biol. 2021 Aug;65(2):222-226. doi: 10.1165/rcmb.2020-0564LE. PMID: 33469586 Free PMC article. Updated. Preprint.
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