PI3Kgamma inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer.
Curcio C, Mucciolo G, Roux C, Brugiapaglia S, Scagliotti A, Guadagnin G, Conti L, Longo D, Grosso D, Papotti MG, Hirsch E, Cappello P, Varner JA, Novelli F.
Curcio C, et al.
J Exp Clin Cancer Res. 2024 Jun 1;43(1):157. doi: 10.1186/s13046-024-03080-1.
J Exp Clin Cancer Res. 2024.
PMID: 38824552
Notably, tumor reduction was abrogated in ENO1 + PI3Kgamma inhibition-treated mice in which B cells were depleted.These data highlight a novel role of PI3Kgamma in B cell-dependent immunity, suggesting that PI3Kgamma depletion strengthens the anti-tumor response eli …
Notably, tumor reduction was abrogated in ENO1 + PI3Kgamma inhibition-treated mice in which B cells were depleted.These data highligh …