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Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Singh L, Donald AE, Foster AC, Hutson PH, Iversen LL, Iversen SD, Kemp JA, Leeson PD, Marshall GR, Oles RJ, et al. Singh L, et al. Among authors: foster ac. Proc Natl Acad Sci U S A. 1990 Jan;87(1):347-51. doi: 10.1073/pnas.87.1.347. Proc Natl Acad Sci U S A. 1990. PMID: 2153294 Free PMC article.
184 results