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Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Vinayak S, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B, Huston CD, Comer E. Vinayak S, et al. Among authors: borrel j. Sci Transl Med. 2020 Sep 30;12(563):eaba8412. doi: 10.1126/scitranslmed.aba8412. Sci Transl Med. 2020. PMID: 32998973 Free PMC article.
Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure.
Ence CC, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, Sharma A, Comer E, Schreiber SL, Melillo B, Sibley LD, Chatterjee AK. Ence CC, et al. Among authors: borrel j. bioRxiv [Preprint]. 2024 Feb 28:2024.02.28.582607. doi: 10.1101/2024.02.28.582607. bioRxiv. 2024. Update in: ACS Infect Dis. 2024 Jun 14;10(6):2212-2221. doi: 10.1021/acsinfecdis.4c00170. PMID: 38464220 Free PMC article. Updated. Preprint.
Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome.
Real de Asua D, Mayer MA, Ortega MDC, Borrel JM, Bermejo TJ, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M. Real de Asua D, et al. Among authors: borrel jm. J Clin Med. 2021 Aug 23;10(16):3748. doi: 10.3390/jcm10163748. J Clin Med. 2021. PMID: 34442043 Free PMC article.
20 results