Schofield CJ - Search Results

1

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase.

Brewitz L, Tumber A, Zhang X, Schofield CJ. Brewitz L, et al. Among authors: schofield cj. Bioorg Med Chem. 2020 Oct 15;28(20):115675. doi: 10.1016/j.bmc.2020.115675. Epub 2020 Aug 6. Bioorg Med Chem. 2020. PMID: 33069066 Free PMC article.

2

Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.

Wright PA, Rostom AA, Robinson CV, Schofield CJ. Wright PA, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1219-21. doi: 10.1016/s0960-894x(00)00194-3. Bioorg Med Chem Lett. 2000. PMID: 10866385

3

Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A.

Kershaw NJ, Mukherji M, MacKinnon CH, Claridge TD, Odell B, Wierzbicki AS, Lloyd MD, Schofield CJ. Kershaw NJ, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2545-8. doi: 10.1016/s0960-894x(01)00494-2. Bioorg Med Chem Lett. 2001. PMID: 11549466

4

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559

5

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.

Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492

6

The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity.

Turnbull JJ, Nagle MJ, Seibel JF, Welford RW, Grant GH, Schofield CJ. Turnbull JJ, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3853-7. doi: 10.1016/s0960-894x(03)00711-x. Bioorg Med Chem Lett. 2003. PMID: 14552794

7

A prodrug system for hydroxylamines based on esterase catalysis.

Conejo-Garcia A, Schofield CJ. Conejo-Garcia A, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4004-9. doi: 10.1016/j.bmcl.2005.06.026. Bioorg Med Chem Lett. 2005. PMID: 15990293

8

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. McDonough MA, et al. Among authors: schofield cj. J Biol Chem. 2005 Dec 9;280(49):41101-10. doi: 10.1074/jbc.M507528200. Epub 2005 Sep 25. J Biol Chem. 2005. PMID: 16186124 Free article.

9

Inhibitors of the FEZ-1 metallo-beta-lactamase.

Liénard BM, Horsfall LE, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2007 Feb 15;17(4):964-8. doi: 10.1016/j.bmcl.2006.11.053. Epub 2006 Nov 18. Bioorg Med Chem Lett. 2007. PMID: 17157014

10

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ. Liénard BM, et al. Among authors: schofield cj. J Med Chem. 2008 Feb 14;51(3):684-8. doi: 10.1021/jm070866g. Epub 2008 Jan 19. J Med Chem. 2008. PMID: 18205296

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