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Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Miles TJ, Hennessy AJ, Bax B, Brooks G, Brown BS, Brown P, Cailleau N, Chen D, Dabbs S, Davies DT, Esken JM, Giordano I, Hoover JL, Jones GE, Kusalakumari Sukmar SK, Markwell RE, Minthorn EA, Rittenhouse S, Gwynn MN, Pearson ND. Miles TJ, et al. Among authors: hennessy aj. Bioorg Med Chem Lett. 2016 May 15;26(10):2464-2469. doi: 10.1016/j.bmcl.2016.03.106. Epub 2016 Mar 31. Bioorg Med Chem Lett. 2016. PMID: 27055939
DABSO-based, three-component, one-pot sulfone synthesis.
Deeming AS, Russell CJ, Hennessy AJ, Willis MC. Deeming AS, et al. Among authors: hennessy aj. Org Lett. 2014 Jan 3;16(1):150-3. doi: 10.1021/ol403122a. Epub 2013 Dec 5. Org Lett. 2014. PMID: 24308313 Free PMC article.
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.
Miles TJ, Hennessy AJ, Bax B, Brooks G, Brown BS, Brown P, Cailleau N, Chen D, Dabbs S, Davies DT, Esken JM, Giordano I, Hoover JL, Huang J, Jones GE, Sukmar SK, Spitzfaden C, Markwell RE, Minthorn EA, Rittenhouse S, Gwynn MN, Pearson ND. Miles TJ, et al. Among authors: hennessy aj. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5437-41. doi: 10.1016/j.bmcl.2013.07.013. Epub 2013 Jul 17. Bioorg Med Chem Lett. 2013. PMID: 23968823
Gold-catalysed cascade rearrangements of ynamide propargyl esters.
Heffernan SJ, Beddoes JM, Mahon MF, Hennessy AJ, Carbery DR. Heffernan SJ, et al. Among authors: hennessy aj. Chem Commun (Camb). 2013 Mar 21;49(23):2314-6. doi: 10.1039/c3cc00273j. Chem Commun (Camb). 2013. PMID: 23399826 Free article.